The highways and byways of mRNA decay

By Nicole Garneau, Jeffrey Wilusz, C. Wilusz. Nature reviews. Molecular cell biology, 2007

1,370 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e6975a343dce9f1b9c96bab0eeca00cb8371e5b9

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Citations in the corpus

P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. (2012, background): “1A) (reviewed in Parker and Song 2004; Garneau et al. 2007) by the major mRNA deadenylase, the Ccr4/Pop2/Not complex (Daugeron et al.”
XRN 5’→3’ exoribonucleases: Structure, mechanisms and functions (2013, neutral): “decapping) and subsequent degradation [2,8].”
mRNA-based therapeutics: powerful and versatile tools to combat diseases (2022, background): “2 Endonuclease-mediated mRNA decay: The mRNA is cleaved into two fragments, and then the fragments are degraded by XRN1 and exosomes.(538) 3 Deadenylation-independent pathways require recruitment of the decapping machinery.”
mRNA-based therapeutics — developing a new class of drugs (2014, neutral): “The catabolism of abberant mRNA (for example, mRNA with a premature stop codon) is controlled by various other mechanisms 231 .”
Database for mRNA half-life of 19,977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cells (2008, background): “For example, ARE-binding proteins can recruit PARN or exosomes.(51) It is also known that the stability of mRNA can be modified by immune factors via AREs in 30-UTR.”
RNA-Binding Proteins in Cancer: Old Players and New Actors. (2017, background): “To initiate decay, either one of these structures must be compromised or the mRNA must be cleaved internally by an endonuclease-mediated reaction [96].”
CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation (2019, positive): “Ribosomes that encounter a PTC in nascent mRNAs, recognized by the assembly of a complex that includes proteins from the ribosome and a 3’ exon-splice junction complex, induces the destruction of the mutant mRNA 3, 4 .”
3D RNA and Functional Interactions from Evolutionary Couplings. (2015, positive): “ Introduction RNAs have diverse known biological roles (Garneau et al., 2007; Huang et al., 2015; Martin and Ephrussi, 2009; McManus and Graveley, 2011; Olsen et al., 1990; Rutherford et al., 2015; Sigova et al., 2015; Warf and Berglund, 2010) and both genetic and biochemical screens suggest…”