P bodies and the control of mRNA translation and degradation.

By R. Parker, Ujwal Sheth. Molecules and Cells, 2007

1,448 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6db210bddee47212e37cb5a34491f21edd5c4f39

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Citations in the corpus

Eukaryotic stress granules: the ins and outs of translation. (2009, background): “…accumulate in two types of cytoplasmic mRNP granules: P-bodies, which generally contain the mRNA decay machinery (reviewed in Anderson and Kedersha, 2006; Parker and Sheth, 2007; Franks and LykkeAndersen, 2008), and stress granules, which contain many translation initiation components (see below).”
Regulation of mRNA translation and stability by microRNAs. (2010, background): “cytoplasmic structures thought to be involved in the storage or degradation of translationally repressed mRNAs (15, 16).”
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018, background): “They are cytoplasmic foci depleted of ribosomes (79) and enriched with enzymatic mRNA degradation machinery, such as mRNA decapping proteins, the CCR4-NOT complex, XRN1, and GW182 family proteins (78).”
siRNA vs. shRNA: similarities and differences. (2009, background): “Whatever the scanning or surveillance mechanism may be, once the target mRNA is identified, the target mRNA is either cleaved or conformationally changed following which both types of structures are routed to the p-body for either sequestration or degradation [103,104].”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “A large number of studies investigating the formation and function of P-bodies have been conducted in yeast.”
Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. (2007, background): “Another type of quality control prior to translation appears to target mRNAs that require localization in the cytoplasm for proper function (Kloc and Etkin 2005; St Johnston 2005; Parker and Sheth 2007).”
Getting to the root of miRNA-mediated gene silencing. (2008, background): “The detection of Argonaute proteins, miRNAs, and miRNA targets in P bodies led to a model in which miRNA targets get sequestered in P bodies, where they are shielded from the translation machinery and may undergo decay (Eulalio et al., 2007b; Parker and Sheth, 2007).”
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets (2009, neutral): “These mechanisms might be similar to those by which Dhh1/Pat1 repress general translation in yeast during carbon starvation (Parker and Sheth, 2007).”
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (2008, background): “The degradation, or at least its final steps, is thought to occur in P-bodies — cellular structures that are enriched in mRNA-catabolizing enzymes and translational repressor”
High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. (2018, background): “In the cytosol of animal cells, two membraneless structures known as the processing body (PB) and the stress granule (SG) are associated with mRNA turnover and protection of mRNA during stress conditions (reviewed in Parker and Sheth, 2007).”