A role for the P-body component GW182 in microRNA function

By Jidong Liu, Fabiola V. Rivas, J. Wohlschlegel, John R. Yates III, R. Parker, Gregory J. Hannon. Nature Cell Biology, 2005

752 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7be68bceb522d586cac404405d15631e5758d19c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

A three-dimensional view of the molecular machinery of RNA interference (2009, background): “melanogaster , the interaction between Argonaute proteins and the P-body protein GW182 is required for miRNA-mediated repression of mRNAs, as well as for Argonaute localizatio”
P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. (2012, background): “P-bodies are dynamic complexes whose assembly is dependent on, and proportional to, the pool of nontranslating mRNA (Liu et al. 2005a; Pillai et al. 2005; Teixeira et al. 2005).”
Control of translation and mRNA degradation by miRNAs and siRNAs. (2006, background): “…versions of the mammalian Argonaute proteins are concentrated in Pbodies and can coimmunoprecipitate with the decapping enzyme (Jakymiw et al. 2005; Liu et al. 2005b; Pillai et al. 2005; Sen and Blau 2005) Similarly, ALG-1, which is one of the Argonaute family members in C. elegans, can accumulate…”
Small silencing RNAs: an expanding universe (2009, neutral): “In addition to an Argonaute protein and a small RNA guide, the RISC might also contain auxiliary proteins that extend or modify its function; for example, proteins that redirect the target mRNA to a site of general mRNA degradatio”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “RISC assembly and activation occurs within the Pbodies, which is supported the co-localization of miRNA duplexes and Ago 1-4 proteins to GW182 [183, 189, 190, 203-206].”
MicroRNAs in development and disease. (2011, background): “Some of the known proteins that form RISC include the RNA-specific endonuclease Dicer, which is involved in the processing of premiRNA into the mature form (259); the argonaute (Ago) protein, which has four isoforms, of which only Ago2, also known as “slicer,” has the capacity to cleave the target m”
The neuronal microRNA system (2006, background): “RISCs reside in cytoplasmic RNA processing bodies ( P bodies ), which contain untranslated mRNAs and can serve as sites of mRNA degradation and storag”
Microarray-based analysis of stress-regulated microRNAs in Arabidopsis thaliana. (2008, background): “Fourteen stress-inducible miRNAs were detected, and our results were further confirmed by detecting their expression patterns and analyzing the cis-elements in their promoter sequences.”