How do microRNAs regulate gene expression?

By I. Cannell, Y. Kong, M. Bushell. Biochemical Society Transactions, 2008

658 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0978eb04faa6e76e8688c36fcaded074d3f8980d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. E. Olson
2. J. Richardson
3. Quynh-Thu Le
4. Michael Story
5. K. Ang
6. T. Nilsen
7. K. Bennewith
8. L. Ding

In Molecular Biology

1. E. Olson
2. R. Bassel-Duby
3. J. Richardson
4. X. Qi
5. Joseph A. Hill
6. T. Pestova
7. C. Hellen
8. Quynh-Thu Le

Citations in the corpus

• An Endothelial-specific microRNA Governs Vascular Integrity and Angiogenesis (2008, background): “Since most miRNAs promote the degradation of their target mRNAs (Jackson and Standart, 2007), we focused on mRNAs that were upregulated in miR-126 / ECs (Table S1).”
• miRecords: an integrated resource for microRNA–target interactions (2008, background): “(5,6)], suggesting that miRNAs could induce translation repression at both the initiation phase and the elongation phase of translation.”
• Hypoxia inducible mir-210 regulates normoxic gene expression involved in tumor initiation (2009, positive): “It has been known that miRNA could regulate its target genes by inhibiting protein translation and/or degrading messenger RNAs (Jackson and Standart, 2007; Nilsen, 2007).”
• Translational control of long-lasting synaptic plasticity and memory. (2009, neutral): “…several disparate mechanisms has been reported: (1) inhibition of translation elongation, (2) inhibition of translation initiation, (3) ribosome drop-off, (4) cotranslational protein degradation, and (5) mRNA degradation (Eulalio et al., 2007; Filipowicz et al., 2008; Jackson and Standart, 2007).”
• Mechanisms of microRNA‐mediated gene regulation (2007, background): “For additional perspectives, see other recent reviews on the mechanistic aspects of miRNA function [4, 5 ].”
• THE MECHANISM OF EUKARYOTIC TRANSLATION INITIATION AND PRINCIPLES OF ITS REGULATION (2010, background): “The degree of repression increases with the increasing number of miRNAs associated with the 3′ UTR, irrespective of whether or not they are identica”