Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.

By B. Oppmann, R. Lesley, B. Blom, J. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, K. Singh and 15 more. 2000

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Citations in the corpus

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain (2003, background): “The cytokine IL-23, which comprises the p40 subunit of IL-12 but a different p19 subuni”
Late Developmental Plasticity in the T Helper 17 Lineage (2009, neutral): “However, early reports that linked IL-23 to induction of IL-17 expression by memory CD4 T cells also demonstrated induction of IFN-g expression (Oppmann et al., 2000), and IFN-g-producing T cells are typically found in association with IL-17-producing T cells in the context”
Structure and signalling in the IL-17 receptor superfamily (2009, neutral): “The basis for this paradox became evident when it was recognized that IL-12p40 is also a component of IL-23 (together with IL-23p19), and so IL-12p40-deficient mice lack both IL-12 and IL-23 (Ref”
IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guérin Infection1 (2007, background): “Instead, IL-23 (but not IL-12) induces the proliferation of memory CD4 T cells and the IL-17 production of CD4 T cells (29, 28, 31).”
Cutting Edge: An In Vivo Requirement for STAT3 Signaling in TH17 Development and TH17-Dependent Autoimmunity1 (2007, background): “Recently, IL-23 was demonstrated to also use the identical p40 subunit, but in this case paired with a unique p19 subunit (7).”
Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine–Nanobody Complex (2017, methodology): “By searching sequence databases for members of the IL6 cytokine family (1), a new protein, designated interleukin (IL) 23p19 was identified.”
The biology of IL-12: coordinating innate and adaptive immune responses. (2003, background): “Microbial products induce the production of p19 in macrophages, DCs, T cells and endothelial cells, and together, p19 and p40 form a novel cytokine, IL-23, with functions similar to, yet distinct from, IL-12 [81].”
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells (2005, background): “One such factor is IL-23, which shares the p40 chain with IL-12 but pairs this with a unique p19 chai”
Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages (2005, background): “Because IL-23 and IL-12 share the common IL-12p40 chain and interact with receptors that share the common IL-12Rβ1 subunit, and because both IFN-γ + and IL-17 + CD4 + T cells can be detected in diseased mice, it has been proposed that there is considerable overlap between the developmental pathwa”
WSX-1 and Glycoprotein 130 Constitute a Signal-Transducing Receptor for IL-27 (2004, background): “Because activated monocytes produce IL-27, as well as its close relatives IL-12 and IL-23, an immediate consequence would be IL-27-dependent autocrine stimulation.”