Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells

By G. Napolitani, A. Rinaldi, F. Bertoni, F. Sallusto, A. Lanzavecchia. Nature Immunology, 2005

1,266 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/309967fc1233a5682367276c300db36c162387c4

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Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines (2008, background): “Combinations of this CD40 agonist antibody with TLR agonists displayed a remarkable synergism in DC activatio”
The perfect mix: recent progress in adjuvant research (2007, background): “58 ), and with associations between TRIF (Toll–interleukin 1 receptor (TIR)-domain-containing adaptor protein inducing IFN-β)-coupled TLRs and non-TRIF-coupled TLRs (see Box 2 ), such as TLR4–TLR7/8, TLR4–TLR9 or TLR3–TLR7/8 (Ref”
Immunological mechanisms of vaccination (2011, background): “Signaling via particular combinations of TLRs results in synergistic activation of DC”
TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis (2005, background): “It has recently been proposed in several studies (46, 49) that TLR signals synergize in the triggering of IL-12 and other Th1-promoting mediators by DCs.”
Cooperation of Toll-like receptor signals in innate immune defence (2007, background): “Further studies indicated that gene expression and protein secretion of TNF, IL-1β, IL-6, IL-10, IL-12, IL-23 and cyclooxygenase-2 were several-fold higher in DCs stimulated with combinations of TLR ligands than in cells stimulated with a single agonis”
Translating innate immunity into immunological memory: implications for vaccine development. (2006, positive): “…such studies should then be used to generate the vaccines of the future—perhaps consisting of multiple TLR ligands that provide both immune synergy (Napolitani et al., 2005) and immune diversity (Querec et al., 2006) in combination with antigen plus or minus synthetic molecules that might…”
Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting (2007, background): “The TLR ligands polyI:C (which signals through TLR3) and R848 act synergistically, resulting in mDCs that are specialized in orchestrating cellular response”
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells (2007, background): “IL-23 shares with IL-12 a common p40 chain and is induced together with IL-12 in maturing dendritic cells (DCs) by several microbial stimul”