IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guérin Infection1

By M. Umemura, A. Yahagi, Satoru Hamada, M. D. Begum, Hisami Watanabe, K. Kawakami, T. Suda, K. Sudo, S. Nakae, Y. Iwakura and 1 more. Journal of Immunology, 2007

599 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/c5162ef5c68848eba50818b64f7a783f1cde4c73

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. A. O’Garra
2. R. Wilkinson
3. Y. Iwakura
4. M. Berry
5. Finlay W Mcnab
6. Paul S. Redford
7. C. Bloom
8. H. Ishigame

In Immunology

1. Y. Iwakura
2. A. O’Garra
3. H. Ishigame
4. Brigitta Stockinger
5. M. Veldhoen
6. D. Cua
7. A. Jetten
8. Shizuo Akira

In Infectious Diseases

1. A. O’Garra
2. R. Wilkinson
3. M. Berry
4. Finlay W Mcnab
5. Paul S. Redford
6. C. Bloom
7. Shizuo Akira

Citations in the corpus

• Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. (2009, background): “For instance, in Mycobacterium tuberculosis (Mtb) infection, gd T cells isolated from the lung are the main primary source of IL-17 (Lockhart et al., 2006; Umemura et al., 2007).”
• The immune response in tuberculosis. (2013, background): “IL-17 may play a role in granuloma formation and Th1 enhancement following BCG infection (285) and in granuloma formation during intratracheal infection with M.”
• Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. (2010, background): “We and others have shown that IL-17A plays important roles not only in the development of autoimmune diseases, but also in the host defense against bacteria (Mangan et al., 2006; Nakae et al., 2003; Schulz et al., 2008; Shiomi et al., 2008; Umemura et al., 2007; Ye et al., 2001).”
• Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “Interestingly, mice lacking IL-17 have been reported to exhibit an attenuated eosinophilic lung inflammation and Th2 cytokine production, while IL-10, which is produced by Treg cells, has been reported to inhibit allergic inflammation [Umemura et al., 2007; Urry et al., 2006].”