A two-step process for thymic regulatory T cell development.

By C. Lio, C. Hsieh. Immunity, 2008

685 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4d8e3e82e3da03e49e22a6cc82586195c0d9502b

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In Immunology

Citations in the corpus

Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? (2009, background): “of cells poised to become nTreg cells because of the strength of their TCR signals, IL-2 or IL-15 can direct a TCR-independent developmental step (Lio and Hsieh, 2008).”
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR (2008, positive): “We find higher Foxp3 induction rates by optimal anti-TCR/CD28 signaling followed by TCR signal deprivation and PI3K/mTOR inhibition, consistent with a recent two-stage model of Treg differentiation in which TCR signals are required for the up-regulation of genes like Cd25 that predispose to Treg dif”
Immunoregulatory Functions of mTOR Inhibition (2009, result): “These findings suggest that rapamycin administration establishes conditions for the initiation of a two-step process of FOXP3 upregulation, which is similar to that described for thymic T Reg cell developmen”
Control of regulatory T cell lineage commitment and maintenance (2009, background): “…in the neonatal thymus and on a prominent role for IL-2 and increased strength TCR signaling in Treg cell differentiation, Lio and Hsieh proposed a two-step model of thymic Treg cell differentiation based on their intrathymic cell transfer studies (Burchill et al., 2008; Lio and Hsieh, 2008).”
Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells (2010, positive): “Lio and Hsieh (24) recently proposed a two-step process for thymic Treg cell development and demonstrated that Foxp3+ Treg cells can develop from the CD4SPFoxp32CD25hi subset.”
Regulatory T Cells: Mechanisms of Differentiation and Function (2012, methodology): “Following the characterization of CD25+Foxp3− precursors of tTreg cells in the neonatal thymus and based on the critical role for IL-2 and also increased TCR signaling strength for tTreg cell differentiation, Lio and Hsieh proposed a two-step model of tTreg cell differentiation (84, 85).”
Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity (2010, positive): “As shown in Figure 2, developing thymocytes that received instructive TCR and CD28 signals developed into Treg cells after signaling through the IL-2R (Burchill et al., 2008; Lio and Hsieh, 2008; Tai et al., 2005).”