T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

By Amy E. Moran, Keli L. Holzapfel, Yan Xing, Nicole R. Cunningham, J. Maltzman, J. Punt, K. Hogquist. Journal of Experimental Medicine, 2011

1,042 citations recorded by the source corpus.

Generation of a Nur77 reporter mouse is used to demonstrate TCR signal strength during thymic selection and peripheral maintenance of conventional and nonconventional T cell subsets and presents a novel tool for studying antigen receptor activation in vivo.

Subfields: Cellular and Molecular Neuroscience, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/0ecd331843627e2d742bc68aae815ecc6e966d23

How researchers see this paper

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In Immunology

1. J. Schenkel
2. Li-Fan Lu
3. D. Masopust
4. Steven Z. Josefowicz
5. Alexander Y. Rudensky
6. S. Kaech
7. Kathryn A. Fraser
8. Lalit K. Beura

In Oncology

1. Steven Z. Josefowicz
2. S. Kaech
3. Alexander Y. Rudensky
4. D. Masopust

Citations in the corpus

• Critical Role for CD103+/CD141+ Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma (2016, neutral): “1, Nur77 mice (Moran et al., 2011), and Cd2-RFP mice (Veiga-Fernandes et al.”
• Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “These characteristics can also affect the cytokine production bias during T helper differentiation (40, 41).”
• Antigen independent differentiation and maintenance of effector-like resident memory T cells in tissues (2012, methodology): “Nur77 is a transcription factor that is transiently expressed upon TCR stimulation (44).”
• IL-2 modulates the TCR signaling threshold for CD8 but not CD4 T cell proliferation on a single cell level (2017, background): “could not be induced by a constitutively active STAT5 construct, consistent with insensitivity of the reporter to IL-2 (4, 7).”
• Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses (2015, background): “First, we observed that the induction of the immediate early gene Nur77 (as measured using a Nur77-eGFP reporter that reads out TCR signaling in a Ca2+-dependent manner; Moran et al., 2011) was suppressed in glucose-poor conditions or in the presence of 2-DG (Figure 3A).”