Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

By K. Aschenbrenner, Louise M. D’Cruz, Elisabeth H. Vollmann, M. Hinterberger, J. Emmerich, L. K. Swee, A. Rolink, L. Klein. Nature Immunology, 2007

604 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/682fbc7877631b19a74cba3ea480020d59ec928c

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In Immunology

1. Shimon Sakaguchi
2. Tomoyuki Yamaguchi
3. T. Nomura
4. M. Ono
5. Alexander Y. Rudensky
6. E. Shevach

Citations in the corpus

• Regulatory T cells and immune tolerance. (2008, background): “A recent study has suggested that Aire + mTECs expressing TSAs may induce or facilitate the development of TSA-specific Tregs in normal thymus, and that a paucity of TSA-specific Tregs may contribute to the occurrence of autoimmune disease in Aire deficiency (Aschenbrenner et al., 2007).”
• T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR (2008, neutral): “Treg development can result from the recognition of tissue-specific antigens expressed by thymic medullallary epithelium (42).”