Early Programming of T Cell Populations Responding to Bacterial Infection1

By R. Mercado, Sujata Vijh, S. Allen, K. Kerksiek, Ingrid M. Pilip, Eric G. Pamer. Journal of Immunology, 2000

602 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/24f4fab53345324fa9bc99e6f7f1fac22a68b4e8

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Citations in the corpus

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells (2010, background): “A single brief T cell receptor (TCR) stimulus (signal 1) combined with costimulation (signal 2) can induce an extended period of proliferation, acquisition of effector functions, and ultimately, memory CTL formation (Kaech and Ahmed, 2001; Mercado et al., 2000; van Stipdonk et al., 2001).”
Vaccines: Effector and memory T-cell differentiation: implications for vaccine development (2002, positive): “In similar types of experiments, CD8 + T cells stimulated for brief periods (2–24 hours) could commit to at least 7–10 cell division”
Translating innate immunity into immunological memory: implications for vaccine development. (2006, positive): “…especially appear to begin a program of cell differentiation and proliferation within hours of exposure of the ‘‘parental’’ cell to antigenic stimulus that results in 7–10 cell divisions over the course of the next few days (Kaech and Ahmed, 2001; van Stipdonk et al., 2001; Mercado et al., 2000).”
Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. (2007, background): “This is plausible because unlike CD8 + T cells (Kaech and Ahmed, 2001; Mercado et al., 2000; van Stipdonk et al., 2001), CD4+ T cells only continue to proliferate in the presence of pMHC (Obst et al.”
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. (2002, neutral): “12 mice (Mercado et al., 2000).”
Memory CD8 T-Cell Differentiation during Viral Infection (2004, background): “without the need for additional antigen (57, 81, 124, 134).”
Immune responses to Listeria monocytogenes (2004, result): “This finding — that clonal expansion of T cells can be antigen independent — is supported by experiments using mice treated with antibiotic”
NK cell development, homeostasis and function: parallels with CD8+ T cells (2011, background): “Does the viral glycoprotein m157 have to be present on DCs in order to prime LY49H + NK cells, or are other cell types sufficient to drive NK cell activation, proliferation and memory generation? Do helper CD4 + T cells have a direct or indirect role in the generation and maintenance of memory NK ”
Signals required for programming effector and memory development by CD8+ T cells (2006, background): “Similarly, Pamer’s (24, 25) and Ahmed’s (26) groups showed that exposure to antigen for 24 h in vivo is sufficient to drive CD8+ T cells through multiple rounds of division.”
Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. (2010, background): “differentiation (Kaech and Ahmed, 2001; Kalia et al., 2006; Mercado et al., 2000; van Stipdonk et al., 2003; van Stipdonk et al., 2001; Williams and Bevan, 2007).”
Shaping and reshaping CD8+ T-cell memory (2008, background): “CD4 + T-cell help A brief interaction with antigen in vitro or in vivo 'programmes' CD8 + T cells with the capacity to differentiate into memory T cell”
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells (2001, positive): “Two recent studies support our theory that, after TCR activation, T cells can continue to proliferate and differentiate independent of further antigenic stimulatio”
CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection (2004, background): “A brief encounter with antigen, as short as 24 h, can initiate 'programmed differentiation' in activated CD8 + T cells that leads to many rounds of antigen-independent division and the acquisition of effector functio”