NK cell development, homeostasis and function: parallels with CD8+ T cells
By Joseph C. Sun, L. Lanier. Nature reviews. Immunology, 2011
677 citations recorded by the source corpus.
Natural killer (NK) cells survey host tissues for signs of infection, transformation or stress and, true to their name, kill target cells that have become useless or are detrimental to the host. For decades, NK cells have been classified as a component of the innate immune system. However, accumulating evidence in mice and humans suggests that, like the B and T cells of the adaptive immune system, NK cells are educated during development, possess antigen-specific receptors, undergo clonal expansion during infection and generate long-lived memory cells. In this Review, we highlight the many stages that an NK cell progresses through during its remarkable lifetime, discussing similarities and differences with its close relative, the cytotoxic CD8+ T cell.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/1cc2e00aed6e5708ee25d7d03b62442705f99fa3
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In Immunology
- M. Colonna
- Chao Yang
- M. Cella
- S. Gilfillan
- Monica S. Thakar
- Alex M. Abel
- S. Malarkannan
- M. Caligiuri
Citations in the corpus
- Intraepithelial type 1 innate lymphoid cells are a unique subset of cytokine responsive interferon-γ-producing cells (2013, positive): “It will be important to 10 Immunity 38, 1–13, April 18, 2013 ª2013 Elsevier Inc. explore the relationship between intraepithelial ILC1 and the recently reported memory NK cells (Cooper et al., 2009; Romee et al., 2012; Sun and Lanier, 2011).”
- The broad spectrum of human natural killer cell diversity (2017, background): “There are many functional and phenotypic similarities between NK cells and T cells, particularly CD8+ T cells (Sun and Lanier, 2011).”
- Natural Killer Cells: Development, Maturation, and Clinical Utilization (2018, background): “Natural killer cells have the unique ability to identify infected cells without direct engagement of the MHC-I complex (12, 218).”