CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection

By Joseph C. Sun, Matthew A. Williams, M. Bevan. Nature Immunology, 2004

781 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/46961218892d5b3fddefab8876d7aecd0081769a

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In Immunology

1. S. Rosenberg
2. N. Restifo
3. M. Bevan
4. V. Badovinac
5. J. Harty
6. Julie M. Curtsinger
7. M. Mescher
8. D. Palmer

Citations in the corpus

• Shaping and reshaping CD8+ T-cell memory (2008, background): “By contrast, adoptive transfer studies of TCR-transgenic T cells in the LCMV infection model showed that, although CD4 + T cells were not essential for a robust primary expansion of the CD8 + T-cell response, they were essential for maintaining memory CD8 + T-cell numbers and functional attribute”
• CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death (2005, background): “It is possible that other cytokines may mediate similar effects on the survival of helpless cell”
• CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells (2005, background): “T cell activation, function, and survival (1, 6, 8).”
• Expanding roles for CD4+ T cells in immunity to viruses (2012, background): “CD4 + T cells seem to be particularly important for maintaining memory CD8 + T cell population”
• Signals required for programming effector and memory development by CD8+ T cells (2006, background): “Most recently, evidence from several groups suggested that the role of CD4 T-cell help may be primarily in allowing generation (73–77) or maintenance (78) of a responsive memory CD8 T-cell population.”
• The immune response during acute HIV-1 infection: clues for vaccine development (2009, result): “, is consistent with the impaired long-term CD8 + T cell memory that has been observed in a model in which mice were depleted of CD4 + T cell”
• Helping the CD8+ T-cell response (2004, background): “Effector or memory CD8 + T cells were isolated and transferred without antigen to new hosts that were either wild-type or CD4 + T-cell deficien”