Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

By S. Kaech, Rafi Ahmed. Nature Immunology, 2001

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Molecular and functional profiling of memory CD8 T cell differentiation. (2002, background): “29, 291–299. were labeled with CFSE (Molecular Probes, Eugene, OR) as deBikah, G., Pogue-Caley, R.R., McHeyzer-Williams, L.J., andscribed in (Kaech and Ahmed, 2001).”
Signals required for programming effector and memory development by CD8+ T cells (2006, background): “Similarly, Pamer’s (24, 25) and Ahmed’s (26) groups showed that exposure to antigen for 24 h in vivo is sufficient to drive CD8+ T cells through multiple rounds of division.”
The Immunological Synapse (2014, background): “The duration of signaling required to initiate proliferation of T cells is at least 2 hours [9–11] but may be much longer to achieve appropriate differentiation of helper T cells [12].”
Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells (2010, background): “A single brief T cell receptor (TCR) stimulus (signal 1) combined with costimulation (signal 2) can induce an extended period of proliferation, acquisition of effector functions, and ultimately, memory CTL formation (Kaech and Ahmed, 2001; Mercado et al., 2000; van Stipdonk et al., 2001).”