Vaccines: Effector and memory T-cell differentiation: implications for vaccine development

By S. Kaech, E. Wherry, Rafi Ahmed. Nature reviews. Immunology, 2002

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Automatic Classification of Cellular Expression by Nonlinear Stochastic Embedding (ACCENSE) (2013, background): “These phenotypes are dynamic and alterations often occur, for example during the differentiation of lymphocytes from naive to memory cells upon encountering their specific antigens (1).”
Memory CD8 T-Cell Differentiation during Viral Infection (2004, background): “cells and secrete antiviral cytokines in response to antigenic stimulation (9, 25, 47, 58, 60, 88, 130).”
mRNA Vaccines Induce Durable Immune Memory to SARS-CoV-2 and Variants of Concern (2021, neutral): “These kinetics are consistent with a typical T cell response after the effector phase (53).”
Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. (2007, background): “In particular, a subset of effector CD8+ T cells can be identified that already expressed certain features of memory CD8+ T cells, such as increased IL-7R expression (Huster et al., 2004; Kaech et al., 2003).”