Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain.

By E. Laywell, P. Rakic, V. G. Kukekov, Eric C. Holland, D. Steindler. Proceedings of the National Academy of Sciences of the United States of America, 2000

755 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/23e64f20a653939cb8f23b985f5d342a3b57ee59

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Citations in the corpus

LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal. (2002, methodology): “to five LeX cells were plated per Terasaki well, approxi- up BrdU and that physically isolated ependymal cells could not generate typical neurospheres (Doetsch et al., mately one in four generated neurospheres. LeX cells that do not generate neurospheres may be stem cells 1999a; Chiasson et al., 199”
LIF and BMP signaling generate separate and discrete types of GFAP-expressing cells (2005, background): “This may reflect an FGF2-mediated increase of EGFR expression (Lillien and Raphael, 2000).”
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells (2006, result): “Additional independent reports provide support for the concept that multipotent neural precursors with similarities to astrocytes contribute to adult neurogenesis (Laywell et al. 2000).”
For the long run: maintaining germinal niches in the adult brain. (2004, background): “Though these cellular young astrocytes isolated from multiple brain regionspopulations are spatially isolated and subserve differbefore postnatal day 10 can give rise to neurospheres—ent brain systems, common themes begin to define neural stem cells in vitro (Laywell et al., 2000).”
Human cortical glial tumors contain neural stem‐like cells expressing astroglial and neuronal markers in vitro (2002, background): “In this respect, the previous study (Laywell et al., 2000) reinforces a notion that potential abnormal astrocytic developmental multipotency can take place under different pathological conditions, whereas induction of a myogenic differentiation program mentioned above can result from…”
Radial glia cells are candidate stem cells of ependymoma. (2005, background): “Although unlikely, we acknowledge that ependymoma cancer stem cells could arise from postmitotic ependymal cells that have reacquired the capacity to self-renew (Capela and Temple, 2002; Laywell et al., 2000; Spassky et al., 2005).”
Adult neurogenesis and functional plasticity in neuronal circuits (2006, background): “The dominant hypothesis is that astrocytes in the adult SVZ, which lines the border between the striatum and the lateral ventricle, act as slow-dividing neural stem cells, capable of generating a progeny of neuroblast precursors”
Glial cells generate neurons: the role of the transcription factor Pax6 (2002, result): “This low degree of neurogenesis was consistent with previous result”
A Specialized Vascular Niche for Adult Neural Stem Cells (2008, background): “Within the adult SVZ, a subset of glial fibrillary acidic protein (GFAP)-expressing astrocytes (type B cells) are stem cells (Ahn and Joyner, 2005; Doetsch et al., 1999a; Garcia et al., 2004; Imura et al., 2003; Laywell et al., 2000; Sanai et al., 2004).”
Infusion of Brain-Derived Neurotrophic Factor into the Lateral Ventricle of the Adult Rat Leads to New Neurons in the Parenchyma of the Striatum, Septum, Thalamus, and Hypothalamus (2001, background): “In fact, multipotent progenitor cells have been shown to reside in parenchymal structures of the adult forebrain (Reynolds et al., 1992; Palmer et al., 1995; Marmur et al., 1998; Laywell et al., 2000).”
hGFAP‐cre transgenic mice for manipulation of glial and neuronal function in vivo (2001, background): “Evidence from a number of studies support the idea that GFAP-positive cells are indeed multipotential (Johansson et al., 1999; Doetsch et al., 1999; Laywell et al., 2000), and radial glia may be a normal developmental path toward both neurons and astrocytes (Malatesta et al., 2000; Noctor et al.,…”