Adult neurogenesis and functional plasticity in neuronal circuits

By Pierre Marie Lledo, Mariana Alonso, M. Grubb. 2006

1,429 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. Guo-li Ming
4. James Bradley Aimone
5. A. F. Schinder
6. L. Mongiat
7. R. Duman
8. S. Ge

In Developmental Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. Guo-li Ming
4. James Bradley Aimone
5. A. F. Schinder
6. R. Duman
7. S. Ge
8. L. Mongiat

Citations in the corpus

• Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Once reaching the core of the olfactory bulb, immature neurons detach from the RMS and migrate radially toward glomeruli where they differentiate into different subtypes of interneurons (reviewed by Lledo et al., 2006).”
• A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. (2007, positive): “Are these new neurons merely replacing dying mature neurons, or are they making unique contributions to specific brain functions that could not be achieved by existing mature neurons? Accumulating evidence from behavioral analysis suggests that adult neurogenesis is essential for some forms of learn”
• TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment (2008, background): “Paradoxically, DG NPCs gain a remarkable capacity to respond to various extrinsic and intrinsic stimuli (Lledo et al., 2006; Ming and Song, 2005).”
• Motor imagery and action observation: cognitive tools for rehabilitation (2007, background): “Cortical representations in the adult brain are not fixed or rigid but highly dynamic (Sanes et al. 1988; Salmon and Butters 1995; Buonomano and Merzenich 1998; Kolb and Whishaw 1998; Spitzer 1999; Rossini et al. 2003; Lledo et al. 2006).”
• Neurogenesis Drives Stimulus Decorrelation in a Model of the Olfactory Bulb (2012, background): “Since the ability to generate sodium spikes develops last in adult-born granule cells [13], the balance between local signaling, calcium spikes, and sodium spikes may change with the age of the cell.”
• Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke (2009, background): “8 ), the main cell type that is normally generated from adult lateral ventricle wall stem cell”
• Disruption of Adult Neurogenesis in the Olfactory Bulb Affects Social Interaction but not Maternal Behavior (2010, neutral): “However, an important component of adult neurogenesis is the selection, integration and survival of adult-generated neurons (Lledo et al., 2006).”
• Epigenetic regulation of neurogenesis in the adult mammalian brain (2011, background): “Adult neurogenesis occurs throughout life in two discrete regions of the adult mammalian brain (Ming & Song, 2005; Lledo et al., 2006; Ma et al., 2009a).”
• The potential of neural stem cells to repair stroke-induced brain damage (2009, background): “In many species including mammals and rodents, neurogenesis occurs throughout the life primarily in three brain regions, the subgranular zone of the hippocampal dentate gyrus (DG), the subventricular zone (SVZ) of the lateral ventricles and the posterior periventricular wall [ 70 , 77].”
• The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “Adult neurogenesis is a highly dynamic process that represents a form of structural plasticity that is regulated by a wide variety of intrinsic and extrinsic factors (Duman, 2004a; Lledo et al., 2006).”
• Adult generation of glutamatergic olfactory bulb interneurons (2009, background): “NSCs in the adult SEZ generate GABAergic interneurons integrating into the granule cell layer (GCL) or glomerular layer of the olfactory bul”
• Adult neurogenesis and the plasticity of the dentate gyrus network (2011, background): “The olfactory bulb incorporates new granule cells and periglomerular cells, both of which are inhibitory c-aminobutyric acid (GABA)ergic interneurons (Lledo et al., 2006).”
• Association of olfactory dysfunction with risk for future Parkinson's disease (2008, background): “The neural stem or precursor cells originate in the subventricular zone between the striatum and lateral ventricle, and migrate along the rostral migratory stream to the olfactory bulb where they mature into functioning interneurons.(37,38) Diminished olfactory neurogenesis in mice is associated wit”
• Mathematical framework for large-scale brain network modeling in The Virtual Brain (2015, neutral): “, 2013), with the strength of synaptic connections changing dynamically over time (Sporns et al., 2005; Lledo et al., 2006).”
• Nurturing Nature: How Brain Development Is Inherently Social and Emotional, and What This Means for Education (2019, background): “New neurons continue to form in the brain during adult-hood in response to new experiences (Eriksson et al., 1998; Lledo, Alonso, & Grubb, 2006; Zhao, Deng, & Gage, 2008), but this growth can be inhibited by stress (Mirescu & Gould, 2006; Mirescu, Peters, & Gould, 2004), chronic sleep disruption…”