Infusion of Brain-Derived Neurotrophic Factor into the Lateral Ventricle of the Adult Rat Leads to New Neurons in the Parenchyma of the Striatum, Septum, Thalamus, and Hypothalamus

By Viorica Pencea, K. Bingaman, S. Wiegand, M. Luskin. Journal of Neuroscience, 2001

956 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/224dce4fb2ea44a6be15da6d5843f98becd1d3ab

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In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment (2006, background): “Although infusions of BDNF into the lateral ventricles increase cell proliferation in number of brain regions, there is no effect on neurogenesis in the hippocampus (Pencea et al., 2001).”
Rat forebrain neurogenesis and striatal neuron replacement after focal stroke (2002, background): “Adult striatal neurogenesis also occurred after exogenous brain-derived neurotrophic factor (BDNF) intraventricular infusion or adenoviral-mediated expression of BDNF in ependyma.(49,50) However, BDNF did not induce substantial neocortical neurogenesis in these studies.”
Exercise training increases size of hippocampus and improves memory (2011, background): “BDNF is a putativemediator of neurogenesis and contributes to dendritic expansion (28, 29) and is also critical in memory formation (30–32).”
Neurogenesis in Adult Subventricular Zone (2002, background): “A similar migration has now been described in much larger brains, including those of primates (Kornack and Rakic, 2001; Pencea et al., 2001a).”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “Infusion of BDNF into the lateral ventricles increases neurogenesis in several brain regions but not the hippocampus (Benraiss et al., 2001; Pencea et al., 2001).”
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells (2006, background): “…studies have shown that intraventricularly administered BDNF is not only capable of increasing the proliferation of SVZ precursors, but also able to promote neuronal migration into ectopic areas such as the neostriatum, septum, thalamus and hypothalamus (Benraiss et al. 2001; Pencea et al. 2001b).”
Brain-derived neurotrophic factor. (2004, background): “Like BDNF mRNA, constitutive BDNF protein expression is particularly high in the hippocampus, where the mossy fibre axons of dentate granule cells display BDNF immunoreactivity (Conner et al., 1997).”
Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. (2002, background): “The maturation of regenerated CA1 neurons may therefore proceed over an extended period of timeadult brain albeit at a low frequency (Rietze et al., 2000; Pencea et al., 2001, Gould and Gross, 2002).”
Brain-derived neurotrophic factor and its clinical implications (2015, background): “BDNF is involved in the regulation of activity-dependent synaptic plasticity by pre- and post-synaptic mechanisms [67, 68].”
Electroconvulsive seizure restores neurogenesis and hippocampus‐dependent fear memory after disruption by irradiation (2008, background): “…focus on VEGF and BDNF because expression of these factors is induced in the hippocampus by ECS (Nibuya et al., 1995; Newton et al., 2003), are progenitor cell mitogens (Pencea et al., 2001; Jin et al., 2002) and are implicated in neuronal survival (Storkebaum et al., 2004; Sairanen et al., 2005).”