hGFAP‐cre transgenic mice for manipulation of glial and neuronal function in vivo

By L. Zhuo, M. Theis, I. Álvarez-Maya, M. Brenner, K. Willecke, A. Messing. Genesis, 2001

642 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/ad834a3d7f09745b9f13bd12d68312c7ab9ee8d4

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In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

Mosaic Analysis with Double Markers (MADM) Reveals Tumor Cell-of-Origin in Glioma (2011, positive): “To induce MADM-based recombination, we chose hGFAP- or Nestin-Cre transgenes (termed NSC-Cre hereafter) that are expressed in both embryonic and adult NSCs (Petersen et al., 2002; Zhuo et al., 2001), thereby generating MADM-labeled cells in all NSCs-derived lineages: neurons, astrocytes, oligodendro”
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis (2009, background): “Given that the hGFAP-Cre transgene directs FoxO deletion in NSCs as well as other CNS lineages (Figures S1O–S1Q; Zhuo et al., 2001), we sought to further define the specific impact of FoxO deficiency on NSC proliferation and renewal by using well-established cell culture-based approaches.”
Medulloblastoma can be Initiated by Deletion of patched in Lineage-Restricted Progenitors or Stem Cells (2008, positive): “, 1997), hGFAP-cre mice (Zhuo et al., 2001), and R26R-GFP reporter mice”
Senescence of activated stellate cells limits liver fibrosis (2008, background): “…of efficiently suppressing p53 expression (Dickins et al., 2007) were crossed to mice harboring a tTA (tetracycline-controlled transactivator) transgene expressed from the Gfap promoter (Wang et al., 2004), which, in the liver, is HSC specific (Bataller and Brenner, 2005; Zhuo et al., 2001).”
Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells (2008, background): “Consistently, the hGFAP promoter drove Cre expression in the hippocampal ventricular zone, giving rise to recombined cells in the hippocampus, including the dentate gyru”
Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis (2014, positive): “We observed robust RFP expression in GFAP+ and EAAT2+ cells (Figure S2D); RFP expression was absent in Iba-1+ microglia as well as in ChAT+ neurons in the spinal cord as previously reported (Figure S2C) (Yamanaka et al., 2008; Zhuo et al., 2001).”
Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity (2009, background): “However, caution must be exercised in interpreting transgenic studies, especially if the mice were generated using a transgene with a short promoter segment, as ectopic and variable expression of the transgene is commonly observe”