A Specialized Vascular Niche for Adult Neural Stem Cells

By M. Tavazoie, L. van der Veken, V. Silva-Vargas, Marjorie Louissaint, Lucrezia Colonna, Bushra Zaidi, Jose Manuel García-Verdugo, F. Doetsch. 2008

1,053 citations recorded by the source corpus.

SUMMARY Stem cells reside in specialized niches that regulate their self-renewal and differentiation. The vasculature is emerging as an important component of stem cell niches. Here, we show that the adult sub-ventricular zone (SVZ) neural stem cell niche contains an extensive planar vascular plexus that has specialized properties. Dividing stem cells and their transit-amplifying progeny are tightly apposed to SVZ blood vessels both during homeostasis and regeneration. They frequently contact the vasculature at sites that lack astrocyte endfeet and pericyte coverage, a modification of the blood-brain barrier unique to the SVZ. Moreover, regeneration often occurs at these sites. Finally, we find that circulating small molecules in the blood enter the SVZ. Thus, the vasculature is a key component of the adult SVZ neural stem cell niche, with SVZ stem cells and transit-amplifying cells uniquely poised to receive spatial cues and regulatory signals from diverse elements of the vascular system.

Subfields: Developmental Neuroscience, Genetics, Surgery

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

In Genetics

In Surgery

R. Weinberg

Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “In the adult SVZ, the vasculature comprises an extensive network of planar interconnected blood vessels (Shen et al., 2008; Tavazoie et al., 2008).”
Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain (2011, neutral): “Although BrdU labeling of mechanical z sections from the subventricular zone (SVZ”
Adult SVZ stem cells lie in a vascular niche: A quantitative analysis of niche cell-cell interactions (2008, positive): “25.0% of LRCs were found to be GFAP-GFP+ after GFP staining, similar to the 38% observed using a 6 week chase period (Tavazoie et al., 2008).”
Adult neurogenesis and the olfactory system. (2009, background): “4.3 The Neurovascular Niche Endothelial cells are an important part of the stem cell niche, leading to the term neurovascular niche (Tavazoie et al., 2008).”
Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, positive): “Type B1 cells, in addition to their apical contacts with the CSF, extend a long process terminating in an endfoot that directly contacts blood vessels (Figure 1; Mirzadeh et al., 2008; Tavazoie et al., 2008).”
Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “There is also strong evidence that neural stem cells reside in a perivascular niche (Tavazoie et al., 2008).”
The cerebrospinal fluid provides a proliferative niche for neural progenitor cells (2011, background): “Though vascular sources of secreted proliferative signals are well characterized (Palmer et al., 2000; Shen et al., 2004, 2008; Tavazoie et al., 2008), the apical surfaces of early cortical precursors and their primary cilia do not approximate blood vessels but instead directly contact the…”
The mystery and magic of glia: a perspective on their roles in health and disease. (2008, background): “Twenty years ago, George Somjen began his excellent review on the history of glia by noting how much of today’s research is still directed toward answering questions first asked a century ago (Somjen, 1988).”
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later (2015, background): “In addition, the blood-brain barrier is leaky near clusters of proliferating NSCs, which would allow these cells to more easily access factors in the blood (Tavazoie et al., 2008).”
High Levels of Id1 Expression Define B1 Type Adult Neural Stem Cells (2009, background): “In the SVZ, the two morphologically discernable Id1 cell types were often located nearby (Figure 1B, top inset), suggesting that the GFAP Id1 astrocytes reside in or near the perivascular stem cell niche (Shen et al., 2008; Tavazoie et al., 2008).”