Glial cells generate neurons: the role of the transcription factor Pax6

By N. Heins, P. Malatesta, F. Cecconi, M. Nakafuku, K. L. Tucker, M. Hack, P. Chapouton, Y. Barde, M. Götz. Nature Neuroscience, 2002

740 citations recorded by the source corpus.

Subfields: Cancer Research, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/13ca04e9323df175fa99d84329f64f85ca7bc11d

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Citations in the corpus

The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, background): “Cultured astrocytes have been induced to function as neuronal progenitors by introducing transcription factors (Heins et al. 2002, Berninger et al. 2007).”
Neuronal fate determinants of adult olfactory bulb neurogenesis (2005, background): “These results implicate Pax6 in the regulation of adult neurogenesis, supposedly by means of its coordinated effects on cell proliferation and cell fate as observed in cerebral cortex developmen”
Neurogenesis in the Adult Hippocampus. (2015, background): “Glial features also characterize neural stem cells in the embryonic brain (Noctor et al. 2001, 2002; Heins et al. 2002; Malatesta et al. 2003) and the other neurogenic area in the adult brain, the SVZ (Doetsch et al.”
Adult neurogenesis: from precursors to network and physiology. (2005, background): “174), a transcription factor that promotes neurogenesis (210).”
Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex (2005, background): “The first type, radial glia, are well known structural elements that, in the past few years, have also been recognized as neuronal and glial progenitors (Malatesta et al., 2000; Miyata et al., 2001; Noctor et al., 2001; Heins et al., 2002).”
Cell migration in the forebrain. (2003, background): “Instead, radial glial cells are dynamic components of the developing cortex, which undergo mitosis to produce new neurons (Heins et al. 2002; Malatesta et al. 2000; Miyata et al. 2001; Noctor et al. 2001, 2002).”
A Dlx2- and Pax6-Dependent Transcriptional Code for Periglomerular Neuron Specification in the Adult Olfactory Bulb (2008, background): “…expressed in the ventral telencephalon (Anderson et al., 1997; Eisenstat et al., 1999; Toresson et al., 2000; Toresson and Campbell, 2001), whereas Pax6 governs the generation of glutamatergic neurons (Stoykova et al., 1996; Heins et al., 2002; Kroll and O’Leary, 2005; Nikoletopoulou et al., 2007).”
Type‐2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis (2006, result): “The concept of radial glia-like cells serving as stem cells in the adult hippocampus is in line with similar reports from fetal brain development (Heins et al., 2002; Malatesta et al., 2003; Noctor et al., 2001, 2002) and the adult subventricular zone (Doetsch et al., 1997; Scheffler et al., 2005).”
Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination (2010, neutral): “Overexpression of Pax6 in astrocytes induces neurogenesi”
Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation (2005, background): “As Pax6 is a potent neurogenic gene (Heins et al., 2002), these data indicate that most undifferentiated cells at early stages of the differentiation protocol are neural progenitors, and that more mature cultures contain few neural progenitors or neurons.”
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. (2008, background): “…marker gene expression, 756 Molecular Cell 30, 755–766, June 20, 2008 ª2008 Elsevier Inc. and their ability to recapitulate in vitro the differentiation pathway of Pax6-positive radial glial cells during cortical development in vivo (Bibel et al., 2004; Heins et al., 2002; Plachta et al., 2004).”
Subventricular Zone-Derived Neuroblasts Migrate and Differentiate into Mature Neurons in the Post-Stroke Adult Striatum (2006, background): “Moreover, forced expression of Pax6 (paired box gene 6) (Heins et al., 2002) and a dominantnegative Olig2 (oligodendrocyte lineage transcription factor 2) mutant (Buffo et al.”
The glial identity of neural stem cells (2003, background): “For example, retroviral infection of early postnatal cortical astrocytes with Pax6, expressed in neurogenic cortical radial glia, increases their neurogenic potential in vitro”