The gene encoding phosphodiesterase 4D confers risk of ischemic stroke

By S. Gretarsdottir, G. Thorleifsson, S. T. Reynisdottir, A. Manolescu, S. Jónsdóttir, T. Jonsdottir, T. Gudmundsdóttir, S. Bjarnadottir, O. B. Einarsson, H. M. Gudjonsdottir and 22 more. Nature Genetics, 2003

611 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/21b44aa4e622cf3253081ffc6eee96b703ffb4c7

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Citations in the corpus

Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use (2006, background): “For example, one region of the PDE4D gene was found to confer increased risk of ischemic stroke (Gretarsdottir et al., 2003; Saleheen et al., 2005).”
A genome-wide association study of global gene expression (2007, background): “Human LCLs provide general information about gene expression, even for genes whose primary function is not in these cell”
Genetic determinants of hair, eye and skin pigmentation in Europeans (2007, methodology): “A likelihood procedure described in a previous publicatio”
Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor–positive breast cancer (2007, methodology): “The associated P values were calculated with a standard likelihood ratio χ 2 statistic as implemented in the NEMO software packag”
Neurovascular regulation in the normal brain and in Alzheimer's disease (2004, background): “The discovery that the gene that encodes the cAMP-degrading enzyme phosphodiesterase 4D, present in endothelial and smooth muscle cells, is a risk factor for ischaemic strok”
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke (2004, methodology): “The stroke and PAOD cohorts used in this study have previously been describe”
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes (2007, methodology): “For association analysis, we used standard likelihood ratio statistics, implemented in NEMO softwar”
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 (2007, methodology): “For the association analyses, we used a likelihood procedure described in a previous publicatio”
A common variant associated with prostate cancer in European and African populations (2006, methodology): “As population controls were used, the OR can also be considered an estimate of relative risk (RR) per copy carried based on the multiplicative model of ris”
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction (2009, methodology): “The associated P values were calculated with the standard likelihood ratio χ 2 statistic as implemented in the NEMO software packag”
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes (2007, methodology): “A likelihood procedure described in a previous publicatio”
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm (2008, methodology): “We used standard likelihood ratio statistics, implemented in the NEMO softwar”
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior (2010, methodology): “For case control association analysis, for example, when comparing PAD, lung cancer or nicotine-dependent cases to population controls, we used a standard likelihood ratio statistic, implemented in the NEMO softwar”