A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
By V. Steinthorsdottir, G. Thorleifsson, I. Reynisdottir, R. Benediktsson, T. Jonsdottir, G. Bragi Walters, U. Styrkársdóttir, S. Gretarsdottir, V. Emilsson, Shyamali Ghosh and 35 more. Nature Genetics, 2007
1,099 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/0dc2e1bbeb4b37028f4b1db6caf04d3bde71d64a
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In Genetics
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In Molecular Biology
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Citations in the corpus
- Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes (2012, neutral): “A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.”
- Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis (2010, methodology): “For the previously reported loci, these findings are broadly consistent with those from more detailed physiological studies 6 , 8 , 44 and suggest that, of the newly discovered loci, the risk alleles at CENTD2 modify T2D susceptibility through a detrimental effect on beta-cell function.”
- Consistent Association of Type 2 Diabetes Risk Variants Found in Europeans in Diverse Racial and Ethnic Groups (2010, background): “With the exception of the KCNQ1 locus which was identified in the Japanese population [1,2], all of the well-replicated risk variants were first identified in populations of Northern European ancestry [3–13].”
- Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity (2009, methodology): “The recruitment of the 1,405 T2D cases used in this study has been described previousl”
- Pathogenesis of Type 2 Diabetes Mellitus (2015, neutral): “A great number of studies have suggested that genetic variants in or near KCNJ11, TCF7L2, WFS1, HNF1B, IGF2BP2, CDKN2ACDKN2B, CDKAL1, SLC30A8, HHEX/IDE, KCNQ1, THADA, TSPAN8/ LGR5, DC123/CAMK1D, JAZF1, MTNR1B, DGKB/TMEM195, GCK, PROX1, ADCY5, SRR, CENTD2, ST6GAL1, HNF4A, KCNK16, FITM2-R3HDML-HNF4A, ”
- Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention (2014, background): “The susceptibility loci of T2DM have been discovered by genome-wide association studies (GWAS) since early 2007 [15-21].”