The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

By A. Helgadóttir, A. Manolescu, G. Thorleifsson, S. Gretarsdottir, H. Jonsdóttir, U. Thorsteinsdóttir, N. Samani, G. Gudmundsson, Struan F. A. Grant, G. Thorgeirsson and 16 more. Nature Genetics, 2004

970 citations recorded by the source corpus.

Subfields: Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/f67f710d2078297a5627c29ae6524d11562a89c1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Aldons J. Lusis
2. A. Tedgui
3. Z. Mallat
4. R. Medzhitov

In Physiology

1. A. Tedgui
2. Z. Mallat

Citations in the corpus

• Mammalian lipoxygenases and their biological relevance (2014, background): “gene encoding ALOX5 activating protein (ALOX5AP) were linked to an increased risk for ischemic stroke [311].”
• Mapping the Genetic Architecture of Gene Expression in Human Liver (2008, background): “This same subnetwork also included genes like Tgfbr2 , Pparg , Lpl , Ppm1l , and Alox5ap , all of which have been previously identified and validated as being associated with traits related to obesity, diabetes, cholesterol levels, and cardiovascular disease [25,31–33].”
• Cytokines in atherosclerosis: pathogenic and regulatory pathways. (2006, background): “Most recently, a significant association was drawn between the gene encoding 5-LO activating protein (FLAP) and myocardial infarction by analysis of single-nucleotide polymorphism haplotype in humans (279).”