Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

By Daniel Fannar Gudbjartsson, U. Bjornsdottir, E. Halapi, A. Helgadóttir, P. Sulem, G. Jónsdóttir, G. Thorleifsson, Hafdís T. Helgadóttir, V. Steinthorsdottir, Hreinn Stefansson and 63 more. Nature Genetics, 2009

831 citations recorded by the source corpus.

Subfields: Immunology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/6fe838908004e3a49a410d3b3dace08fd50832a3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Andrew N. J. McKenzie
2. Joshua Charles Denny
3. D. Umetsu
4. N. Baumgarth
5. R. DeKruyff

In Physiology

1. Carole Ober
2. Joshua Charles Denny
3. Manolis Kellis
4. T. Yao
5. Jason Ernst

In Surgery

1. Andrew N. J. McKenzie
2. Joshua Charles Denny
3. D. Umetsu
4. R. DeKruyff

Citations in the corpus

• The Genetics of Asthma and Allergic Disease: A 21st Century Perspective (2011, background): “This first asthma GWAS was followed by many others of asthma (210–214), atopic dermatitis (215), eosinophilic esophagitis (EoE) (216), atopy (217) and the asthma ⁄ allergy intermediate quantitative traits, YKL-40 levels (66), total serum IgE (67), eosinophil count (68), and lung function (FEV1, FEV1”
• Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity (2011, background): “, and in genome-wide association studies, IL33 has been identified as a susceptibility gene for human asthm”
• Discovery and characterization of chromatin states for systematic annotation of the human genome (2010, background): “4b ), a SNP reported to be strongly associated with plasma eosinophil count levels in inflammatory diseases (rs12619285”
• Extracting research-quality phenotypes from electronic health records to support precision medicine (2015, background): “So far the company has isolated genes thought to be involved in several diseases, such as gout [62], cardiovascular disease [63], cancer [64] and schizophrenia [65].”
• Genome-wide association studies: what do they teach us about asthma and chronic obstructive pulmonary disease? (2009, background): “A second GWA study on asthma was a substudy of a GWA scan on eosinophil counts in blood of 9,392 Icelanders ( 5 ).”
• The IL-1 family: regulators of immunity (2010, background): “Polymorphisms in both human IL33 and IL1RL1 (the gene encoding ST2) are associated with increased numbers of circulating eosinophil”