Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use

By Andrew T. Bender, J. Beavo. Pharmacological Reviews, 2006

1,781 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/2d23adf124e4750303c0606e95a1fd818d6f4d1f

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In Molecular Biology

1. J. Corbin
2. J. Garthwaite
3. S. Francis

In Pharmacology

1. J. Garthwaite

In Psychiatry and Mental health

1. J. Garthwaite

Citations in the corpus

• Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions. (2011, background): “In the presence of calcium, PDE1 is comprised of two calmodulin subunits that interact with two identical catalytic subunits (30, 355).”
• Concepts of neural nitric oxide-mediated transmission (2008, background): “…photoreceptor cells, PDE6, resulting in heightened catalytic activity and cGMP breakdown. cGMP is a lowefficacy substrate for another PDE, PDE3, so that cGMP binding to the catalytic site leads to inhibition of cAMP hydrolysis, potentially raising cAMP levels (reviewed by Bender & Beavo, 2006).”