The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

By A. Helgadóttir, G. Thorleifsson, K. Magnússon, S. Gretarsdottir, V. Steinthorsdottir, A. Manolescu, Gregory T. Jones, Gabriel J. E. Rinkel, J. Blankensteijn, A. Ronkainen and 58 more. Nature Genetics, 2008

782 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/24db39fc6295bfcc8a9c83d6ca63a7decc0ecb29

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Gonçalo R. Abecasis
2. Mark J. Daly
3. Cristen J. Willer
4. Yurii S. Aulchenko
5. David Altshuler
6. Michael Boehnke
7. Eric E. Schadt
8. J. Thompson

In Immunology

1. Johan L. M. Björkegren
2. F. S. Collins
3. Joshua Charles Denny
4. N. Sharpless
5. C. Betsholtz

In Pulmonary and Respiratory Medicine

1. Børge G. Nordestgaard
2. Sekar Kathiresan

Citations in the corpus

• Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease (2017, positive): “Furthermore, several loci show association with other diseases; for example, the CADassociated variants in the chromosome 9p21 locus also associate with risk of stroke as well as abdominal, aortic, and intracranial aneurysms (3,4).”
• Human genetic variation and its contribution to complex traits (2009, neutral): “, abdominal aortic aneurysm and intracranial aneurys”
• The care of patients with an abdominal aortic aneurysm: the Society for Vascular Surgery practice guidelines. (2009, background): “A recent large study has suggested that a common sequence variant on 9p21, rs10757278-G, is associated with a 31% increased risk of abdominal aortic aneurysm.(114) Genome wide screening may serve to identify additional genetic markers for disease, which may further assist in targeting early ultrasou”
• Pathophysiology and epidemiology of abdominal aortic aneurysms (2011, background): “3) in a subgroup analysis of a worldwide GWAS for coronary heart disease”
• Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk (2010, background): “disease, stroke, myocardial infarction and aortic aneurysm) [2–12].”
• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis (2010, result): “If we include the KCNQ1 associations described above, previous reports at JAZF1 , CDKN2A and CDKAL1 (refs”