Neurovascular regulation in the normal brain and in Alzheimer's disease

By C. Iadecola. Nature Reviews Neuroscience, 2004

2,244 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/dd665e4c87db2ca9c2696c46b27ee1f46f1d5eee

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Citations in the corpus

Resting-state functional connectivity in the human brain revealed with diffuse optical tomography (2009, background): “, 2008) or altered (as with brain injury) (Fujiwara et al., 2004; Bonakdarpour et al., 2007; Zou et al., 2005; Iadecola, 2004; D'Esposito et al., 2003).”
Astrocyte–endothelial interactions at the blood–brain barrier (2006, background): “In astrocytes, this can trigger the production of interleukin-6 (IL-6) through activation of nuclear factor-κB (NF-κB) (1).”
Vascular Cognitive Impairment and Dementia (2019, background): “For example, reactive oxygen species (ROS) scavenge NO or suppress NO synthesis by inactivating critical cofactors (10).”
Blood-Brain Barrier Breakdown in the Aging Human Hippocampus (2015, neutral): “…biomarkers of endothelial cell injury such as soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) (Iadecola, 2004; Zlokovic, 2008); no change in the inflammatory response as shown by unaltered CSF levels of several studied cytokines (e.g.,…”
Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. (2006, background): “The mechanisms underlying neurovascular coupling have been the subject of enquiry for more than a century (31), and numerous vasoactive factors have been implicated in neurovascular coupling (Table 1).”
Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis (2016, methodology): “Subsequently, and based on this distance/abnormality metric (4), for each descriptor i a total abnormality index (AbHC!LOAD i E [0, 1]) was evaluated, summarizing its normalized dissimilarity with healthy aging across the entire disease/aging progression interval, in the HC to LOAD trajectory: AbHC!”
The pathobiology of vascular dementia (2013, neutral): “…with early AD or at risk for AD (Claassen et al., 2009; Gao et al., 2013; Luckhaus et al., 2008; Mentis et al., 1996; Niedermeyer, 2006; Ruitenberg et al., 2005; Sabayan et al., 2012; Tanaka et al., 2002), implicating reduced cerebral perfusion in the pathobiology of the disease (Iadecola, 2004).”
Perivascular nerves and the regulation of cerebrovascular tone. (2006, background): “A better understanding of specific proteins such as connexins and integrins in these retrogradely transmitted vascular responses appears essential to fully appreciate their contribution in this particularly important regulatory mechanism in brain (3, 20, 32).”
Glial regulation of the cerebral microvasculature (2007, background): “Thus, the cerebral circulation is endowed with control mechanisms that ensure that the brain receives an adequate blood supply at all time”
The blood-brain barrier in health and chronic neurodegenerative disorders. (2008, neutral): “The link between ischemia and increased Ab production (Iadecola, 2004), on one hand, and the accumulation of hyperphosphorylated tau in cortical neurons and filament formation similar to that present in human neurodegenerative tauopathies and AD (Gordon-Krajcer et al., 2007; Wen et al., 2007), on…”
Central nervous system pericytes in health and disease (2011, background): “Future studies are needed to more clearly delineate the role of pericytes in the context of the well-established role of VSMCs of small pial and intracerebral arteries in mediating CBF responses to neuronal activit”
Vascular Contributions to Cognitive Impairment and Dementia Including Alzheimer’s Disease (2014, background): “Decreased blood flow prior to beta-amyloid (Aβ) deposition has been observed in the brain of both mouse models of AD and in individuals with AD, and has been proposed to contribute directly to the cognitive symptoms and, some studies suggest the changes in the vasculature impair clearance of Aβ, and”