Epithelial NEMO links innate immunity to chronic intestinal inflammation

By Arianna Nenci, C. Becker, A. Wullaert, R. Gareus, G. van Loo, S. Danese, M. Huth, A. Nikolaev, C. Neufert, B. Madison and 3 more. Nature, 2007

1,142 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/211db2b67523a4a9cb683869f07a7108d99f6fb6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. M. Karin
2. Shao-Cong Sun
3. T. Lawrence
4. M. Abreu
5. Y. Ben‐Neriah
6. Ting Liu
7. Lingyun Zhang
8. Donghyun Joo

In Immunology

1. M. Karin
2. K. Honda
3. Shao-Cong Sun
4. Dan R. Littman
5. T. Lawrence
6. L. Franchi
7. Y. Ben‐Neriah
8. N. Warner

In Surgery

1. M. Abreu
2. G. Núñez
3. K. Honda
4. Wenjun Ouyang
5. Yan Zheng
6. Dan R. Littman
7. Hans Clevers
8. Markus F. Neurath

Citations in the corpus

• Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “Similarly, loss of NEMO, a protein critical for NF-jB activation via multiple proinflammatory pathways, leads to spontaneous colitis presumably triggered by the presence of commensal bacteria in the lamina propria (117).”
• NF-κB signaling in inflammation (2017, positive): “107,108 Thus, aberrant activation of NF-κ B or its genetic deficiency may both contribute to the pathogenesis of IBD, with its functions differing between innate immune cells and epithelial cells.”
• Application of Probiotics in Shrimp Aquaculture: Importance, Mechanisms of Action, and Methods of Administration (2016, background): “…the digestive tract by the probiotic bacteria has been reported by several authors (Kabir et al., 2005; Trachoo and Boudreaux, 2006; Anukam, 2007; Nenci et al., 2007; Raj et al., 2008; Hung et al., 2008; Radfar and Farhoomand, 2008; Capcarova et al., 2008; Soundarapandian and Sankar, 2008;…”
• Caspase-8 regulates TNF-alpha induced epithelial necroptosis and terminal ileitis (2011, positive): “Furthermore, recent data have indicated a role of caspase-mediated apoptosis of IEC in the pathogenesis of inflammatory bowel diseases (IBD) like Crohn's disease and ulcerative colitis 5,6 .”
• Inflammation and cancer: An ancient link with novel potentials (2007, background): “IKK-g- or NEMO-deficient mice showed severe deregulation of immune homoeostasis in the gastro-intestinal tract and an inflammatory bowel diseaselike phenotype.(74) The inhibition of IKK-b-dependent activation of NF-jB leads to the decrease in tumor incidence in inflammationassociated murine models o”
• Dendritic cells in intestinal immune regulation (2008, background): “In fact, TLR signalling and NF-κB activation in IECs in the steady state may have an important role in intestinal immune homeostasi”
• The Microbiome in Infectious Disease and Inflammation (2012, positive): “Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis.”
• RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells (2009, background): “It is believed that intestinal lymphocytes are involved in this homeostatic balance between the commensal microflora and intestinal epithelial cell”
• Inflammation meets cancer, with NF-κB as the matchmaker (2011, background): “An even more severe and spontaneous inflammatory condition has been observed in mice devoid of IKKγ (NEMO) in IECs; these mice have an almost complete loss of NF-κB activity in these cell”