RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

By Stephanie L. Sanos, Viet L Bui, A. Mortha, K. Oberle, Charlotte Heners, C. Johner, A. Diefenbach. Nature Immunology, 2009

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Subfields: Immunology

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Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “1int) [Cupedo et al., 2009; Luci et al., 2009; Sanos et al., 2009] (Figure 4).”
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus (2011, background): “Signals derived from commensal bacterial communities have also been linked to the development and/or activation of several ILC subset”
The role of gut microbiota in immune homeostasis and autoimmunity (2012, background): “As GF mice lack IL-22-producing NKp46 cells, this suggests that the gut microbiota may play a crucial role in promoting IL-22NKp46 cell differentiation.(34) Mast cells represent 2–3% of lamina propria (LP) cells in the GI tract.”
The transcription factor GATA3 controls cell fate and maintenance of type 2 innate lymphoid cells (2012, neutral): “This is consistent with our previous data (Sanos et al., 2009) and in contrast to splenic NK cells (Hanke et al.”