Dendritic cells in intestinal immune regulation

By J. Coombes, F. Powrie. Nature reviews. Immunology, 2008

836 citations recorded by the source corpus.

A breakdown in intestinal homeostasis can result in chronic inflammatory diseases of the gut including inflammatory bowel disease, coeliac disease and allergy. Dendritic cells, through their ability to orchestrate protective immunity and immune tolerance in the host, have a key role in shaping the intestinal immune response. The mechanisms through which dendritic cells can respond to environmental cues in the intestine and select appropriate immune responses have until recently been poorly understood. Here, we review recent work that is beginning to identify factors responsible for intestinal conditioning of dendritic-cell function and the subsequent decision between tolerance and immunity in the intestine.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/7af66adb3c40e9c518541d70f9ebb69234a52984

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Y. Belkaid
2. Steffen Jung
3. C. Varol
4. J. Turner
5. F. Powrie
6. Christopher A. Hunter
7. K. Murphy
8. K. Maloy

Citations in the corpus

• Inflammatory Cytokines in Depression: Neurobiological Mechanisms and Therapeutic Implications (2013, background): “The intestinal lining also harbors immune cells, including dendritic cells and T cells (Coombes and Powrie, 2008, Fagarasan et al., 2010), and may serve as a source of circulating cytokines.”
• Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells (2010, background): “CD103+ DCs of the lamina propria (LP) and mesenteric lymph nodes (MLNs) have been shown in vitro to promote the expression of specific integrins and chemokine receptors on T cells, and to direct the differentiation of CD4+Foxp3+ T reg cells, and are thought to be important components of intestinal h”
• Intestinal lamina propria dendritic cell subsets have different origin and functions. (2009, background): “Retinoic acid-producing CD103 lpDCs were reported to imprint a4b7 and CCR9 expression on naive lymphocytes to establish gut tropism, as well as to induce FoxP3 T regulatory cells (Coombes and Powrie, 2008).”
• Intestinal homeostasis and its breakdown in inflammatory bowel disease (2011, background): “Adaptive regulation of intestinal inflammation The intestine contains an extensive network of dendritic cells and macrophages that has an important role in shaping adaptive immunity in response to intestinal environmental cue”
• Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection (2009, background): “addition to various populations of Treg cells, the GI tract is home to dendritic cells (DCs) displaying regulatory functions via their capacity to release cytokines or to induce Treg cells (Coombes and Powrie, 2008).”
• Intestinal mucosal barrier function in health and disease (2009, background): “Finally, detailed analyses of the interactions between epithelial cells and luminal microorganisms, as well as the intricacies of mucosal immune regulation, have also been recently reviewed elsewher”
• Nod2 is required for the regulation of commensal microbiota in the intestine (2009, background): “Third, it is possible that Nod2 expression in the myeloid lineage cells may contribute indirectly to the regulation of microbiota (35).”
• Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa (2011, background): “Activated DCs produce co-stimulatory molecules, including transforming growth factor-β, retinoic acid and cytokines such as IL-10, in ratios that depend on the mode of DC stimulation (in this case, MAMP exposure); DCs can also modulate the activation, clonal expansion and differentiation of T cell”