Function of Nod‐like receptors in microbial recognition and host defense

By L. Franchi, N. Warner, Kyle L. Viani, G. Núñez. Immunological Reviews, 2009

893 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/c6792667634a0f1fad245869a2a08ec62bea15b7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Shizuo Akira
2. Taro Kawai
3. G. Núñez
4. Himanshu Kumar
5. E. Latz
6. L. Franchi
7. H. Kono
8. N. Warner

In Molecular Biology

1. G. Núñez
2. E. Latz
3. Shizuo Akira
4. Taro Kawai
5. Yuan He
6. Himanshu Kumar
7. N. Inohara
8. L. Franchi

Citations in the corpus

• Mechanism and regulation of NLRP3 inflammasome activation (2016, background): “oligomerization domain that mediates self-oligomerization; and carboxy-terminal LRRs that are thought to be involved in recognition of stimuli [9].”
• The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation (2019, background): “the NACHT domain), and a C-terminal leucine-rich repeat (LRR) domain [12].”
• Sensing and Reacting to Microbes via the Inflammasomes (2012, background): “Once activated, caspase-1 proteolytically cleaves the cytokine precursors pro-interleukin 1β (pro-IL-1β) and pro-IL-18; this is critical for release of the biologically active forms (L-1β and IL-18) and triggers proinflammatory and antimicrobial response”
• Cytokines in Inflammatory Disease (2019, background): “, via mitogen-activated protein (MAP) kinase signaling pathways to nuclei where diverse transcription factors, such as nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells (NF-κB) get activated and induce a cellular response [13].”
• Activation of innate immune antiviral response by NOD2 (2009, background): “For example, the NLR Nod2 detects bacterial PAMPs, including muramyl dipeptide (MDP”
• Kupffer Cells in the Liver (2013, neutral): “Caspases are intracellular cysteine proteases that cleave substrates after aspartate residues and play integral roles in apoptosis (29).”
• NOD1 and NOD2: signaling, host defense, and inflammatory disease. (2014, background): “Consistent with a role for NOD1 and NOD2 in host responses against bacterial infection, Nod1 / and Nod2 / mice show enhanced susceptibility to several pathogens (Franchi et al., 2009; Philpott et al., 2014).”
• RNA-based antiviral immunity (2010, background): “Families of well-characterized pattern recognition receptors (PRRs) include the Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs), which were first cloned in Drosophila melanogaster , plant and mammalian systems, respectivel”
• Pathogen Recognition by the Innate Immune System (2011, background): “Recently, several reports showed that the pathogenic fungus, Candida, and baker’s yeast (Saccharomyces) induced IL-1β via NLRP3, ASC and caspase-1, and further studies revealed that β-glucan, a major component of fungal cell walls, activates the NLRP3 inflammasome [108–115].”
• Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives (2020, background): “Thus, while pro-fibrotic macrophages have been characterized by a high expression of Ly-6C or Gr1 [16], CD11bneg macrophages with low expression of Ly-6C are associated with MMPs production and fibrosis resolution [236,237].”
• The sterile inflammatory response (2010, background): “There are inflammasomes containing the NLRP1, NLRP3, NLRC4 and AIM-2 NLR proteins, and since there are many more NLR proteins there may be other complexes yet to be discovered (71).”
• Programmed cell death in the plant immune system (2011, background): “The best studied to date are the NLR inflammasomes, which sense mostly MAMPs and DAMPs.(14) These supramolecular complexes are assembled via NLR N-terminal domain homotypic interactions.”
• Immune cell regulation by autocrine purinergic signalling (2011, background): “Inflammasome activation triggers innate immune defences by inducing the maturation of pro-inflammatory cytokines, such as IL-1β, in a caspase 1-dependent manne”