Inflammation meets cancer, with NF-κB as the matchmaker

By Y. Ben‐Neriah, M. Karin. Nature Immunology, 2011

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NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review (2015, background): “Moreover, this pathway is implicated in cell proliferation and survival, demonstrated by constitutively active NF-κB signaling in many tissues (Ben-Neriah and Karin, 2011).”
Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches (2016, background): “In addition, some tumor cells secrete factors that cause NF-κB to become active [39,40].”
The complexity of NF-κB signaling in inflammation and cancer (2013, background): “On the other hand, a tumor can achieve elevated NF-κB activity through increased cytokine release from the tumor microenvironment [76].”
Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma (2013, background): “For example, NF-kB promotes an inflammatory response through secretion of TNF-a, IL-1b, and IL-6, of which IL-6 triggers STAT3 activation (Ben-Neriah and Karin, 2011; Hayden and Ghosh, 2012).”
Role of macrophage targeting in the antitumor activity of trabectedin. (2013, background): “The last decade witnessed an ever-growing awareness of the promoting role of chronic inflammation in cancer initiation and progression (Balkwill and Mantovani, 2001; Ben-Neriah and Karin, 2011; Coussens and Werb, 2002; Mantovani et al., 2008; Murray and Wynn, 2011).”