The epigenomics of cancer.

By Peter A. Jones, S. Baylin. Cell, 2007

4,577 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ff48858ce717b18a950ea6c4749c4382e661c21f

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Citations in the corpus

Hallmarks of cancer: the next generation. (2011, neutral): “, inactivation of tumor suppressor genes, can also be acquired through epigenetic mechanisms such asDNAmethylation and histonemodifications (Berdasco and Esteller, 2010; Esteller, 2007; Jones and Baylin, 2007), some clonal expansions may well be triggered by nonmutational changes affecting the regul”
Membership Privacy in MicroRNA-based Studies (2016, background): “Even though biomedical research on miRNAs is far from complete, studies of miRNA expression proﬁles have already shown that dysregulation of miRNA is linked to neurodegenerative diseases, heart disease, diabetes, and the majority of cancers [27, 35, 21, 29, 15].”
DNA methylation: The nuts and bolts of repression (2007, background): “Since then it has been shown that although the genome as a whole is hypomethylated in cancer, many CpG islands are hypermethylated (Jones and Baylin, 2007).”
Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling (2016, background): “Widespread aberrations in DNA methylation are a well-established hallmark of many cancers [1] and a growing body of literature shows a role for DNA methylation in the aetiology of other complex human diseases including chronic kidney disease [2], type 2 diabetes [3] and neuropsychiatric disease [4].”
Epigenetic Modifications as Therapeutic Targets (2010, background): “Expression of the DNA repair gene O(6)-methylguanine-DNA methyltransferase (MGMT) antagonizes chemotherapy and radiation treatment23.”
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. (2010, background): “Cancer-specific DNA methylation changes are hallmarks of human cancers, in which global DNA hypomethylation is often seen concomitantly with hypermethylation of CpG islands (reviewed in Jones and Baylin, 2007).”
Interpreting thelanguage of histone and DNA modifications (2014, background): “Waves of DNAmethylation reprogramming also occur through germ cell development and carcinogenesis, recently reviewed elsewhere [196,197].”
Functional normalization of 450k methylation array data improves replication in large cancer studies (2014, neutral): “their methylome compared to normal samples from the same tissue of origin, making the marginal distribution of methylation across the genome different between cancer and normal samples [4-8]; see Additional file 1: Figure S1 for an example of such a global shift.”
Detection and quantification of rare mutations with massively parallel sequencing (2011, background): “This strategy also permitted the use of degraded or damaged DNA, such as found in clinical specimens or after bisulfite treatment for the examination of cytosine methylation (45).”