Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.

By K. Takubo, Go Nagamatsu, C. Kobayashi, A. Nakamura-Ishizu, Hiroshi Kobayashi, Eiji Ikeda, N. Goda, Y. Rahimi, Richard J. Johnson, Tomoyoshi Soga and 3 more. Cell Stem Cell, 2013

746 citations recorded by the source corpus.

Subfields: Cancer Research, Hematology, Surgery

View Paper: https://www.semanticscholar.org/paper/1c89f226f35060f86435e189d10b158325a5abbc

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In Cancer Research

1. Manu N. Setty

In Surgery

1. Joachim L. Schultze
2. G. Hajishengallis

Citations in the corpus

• Characterization of cell fate probabilities in single-cell data with Palantir (2019, positive): “Studies have shown that hematopoietic stem cell (HSC) differentiation requires an exit from the slow-cycling, quiescent long-term HSC (LT-HSC) state to a metabolically active short-term HSC (ST-HSC) state, a process known as the metabolic switch 23 .”
• Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity (2018, background): “…(Simsek et al., 2010; Takubo et al., 2013; Wang et al., 2014), whereas the activation of OXPHOS is associated with their functional impairment, loss of self-renewal potential, and induction of DNA damage (Suda et al., 2011; Takizawa et al., 2017; Takubo et al., 2013; Walter et al., 2015).”