A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche.

By Yoon-Young Jang, S. Sharkis. Blood, 2007

901 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/635c83b45f90281e38990e55c99b1ac4dd842d5f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. G. Semenza
2. T. Suda
3. G. Sauvageau
4. K. Takubo
5. Martin Sauvageau
6. D. Scadden
7. C. V. Dang
8. Navdeep S. Chandel

In Hematology

1. G. Semenza
2. T. Suda
3. G. Sauvageau
4. K. Takubo
5. Martin Sauvageau
6. D. Scadden
7. S. Morrison

In Pulmonary and Respiratory Medicine

1. T. Suda
2. G. Sauvageau
3. K. Takubo
4. Martin Sauvageau
5. G. Semenza

Citations in the corpus

• BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells (2013, methodology): “Our findings in LSC-enriched populations, and previous studies in breast CSCs, indicate a low oxidative state as a potentially frequent CSC property (Diehn et al., 2009).”
• Metabolic regulation of hematopoietic stem cells in the hypoxic niche. (2011, methodology): “When HSCs were stained with dihydrodichlorofluorescein diacetate, which is converted to the molecule dichlorofluorescein (DCF) in the presence of ROS, DCFhigh and DCFlow HSCs were seen and the latter retained higher reconstitution ability than the former (Jang and Sharkis, 2007).”
• Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. (2010, positive): “Interestingly, antioxidant treatment of stem cells with high ROS levels restores their long term self-renewal potential (Ito et al., 2004; Jang and Sharkis, 2007; Zhang et al., 2007).”
• Oxidative Stress, Mitochondrial Dysfunction, and Aging (2011, background): “Mitochondrial oxidative stress induced by partial loss of SOD2 leads to an increase in proton leak, sensitization of the mitochondrial permeability transition pore and premature induction of apoptosis [219].”
• Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? (2009, background): “Recent studies showed that normal haemopoietic stem cells and normal mammary epithelial stem cells maintained ROS at lower levels than their mature progeny to prevent cellular differentiation and maintain long-term self-renewa”
• Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation (2008, background): “The roles of hypoxia in the stem cell microenvironment and ROS in signal transduction are also of great interest and might be a key component of the stem cell nich”
• Oxygen in stem cell biology: a critical component of the stem cell niche. (2010, background): “HSCs present in the hypoxic niche express higher levels of Notch-1, telomerase, and the cell-cycle inhibitor p21 than cells closer to the vasculature (Jang and Sharkis, 2007).”