Applying the principles of stem-cell biology to cancer

By R. Pardal, M. Clarke, S. Morrison. Nature Reviews. Cancer, 2003

1,687 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/122ef8c0bee00286492404cf0847c4d84791a559

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Citations in the corpus

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. (2006, background): “However, the true relatedness of previously reported TSCs to normal stem cells and their exact relevance to our current in vitro and in vivo models of cancer, as well as to primary human tumors in situ, remain unclear (Dontu et al., 2003; Huntly and Gilliland, 2005; Kim et al., 2005; Pardal et al., ”
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “Over the past several years, it has become clear that the growth of at least some cancers is driven by cancer stem cells, particularly malignant cancer cells that are more tumorigenic than other cancer cells (Pardal et al., 2003; Reya et al., 2001).”
Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment (2009, background): “Recently, the cancer stem cell (CSC) theory has been proposed to explain the tumor heterogeneity and the carcinogenesis process (2, 3).”
Normal stem cells and cancer stem cells: the niche matters. (2006, background): “In this sense, cancer may prove to be more of a stem cell disease than previously suspected (13, 15).”
Spontaneous human adult stem cell transformation. (2005, background): “Specific cancer stem cells have been isolated, characterized, and defined in several human tumor types, including acute myeloid leukemia, glioblastoma, and breast cancer, and are proposed to derive from normal adult stem cells (1).”
The biology of cancer stem cells. (2007, background): “…cells may be preferential targets of initial oncogenic mutations because in most tissues in which cancer originates they are the only long-lived populations and are therefore exposed to more genotoxic stresses than their shorter-lived, differentiated progeny (Pardal et al. 2003, Reya et al. 2001).”
Polycomb silencers control cell fate, development and cancer (2006, background): “This is particularly interesting in light of the 'cancer stem cell' hypothesis, which predicts that cells with stem cell characteristics are the main driving force behind tumour proliferation and progressio”
Molecular genetics of prostate cancer: new prospects for old challenges. (2010, background): “The cancer stem cell model proposes that cell populations within a tumor have a hierarchical organization, in which a stem cell-like population gives rise to more differentiated derivatives that lack tumor-initiating and/or long-term self-renewal capability (Reya et al. 2001; Pardal et al. 2003; Wic”
Identification of human brain tumour initiating cells (2004, background): “jpg" NDATA ITEM> ]> The cancer stem cell (CSC) hypothesis suggests that neoplastic clones are maintained exclusively by a rare fraction of cells with stem cell propertie”