Stem cells and niches: mechanisms that promote stem cell maintenance throughout life.

By S. Morrison, A. Spradling. 2008

1,977 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Hongjun Song
2. Guo-li Ming
3. Fred H. Gage
4. D. Peterson
5. D. C. Lie
6. S. Morrison
7. P. Bonaldo
8. F. Gattazzo

In Molecular Biology

1. Hongjun Song
2. Guo-li Ming
3. Fred H. Gage
4. S. Morrison
5. Shenghui He
6. Daisuke Nakada
7. D. Peterson
8. M. Götz

In Oncology

1. Guo-li Ming
2. Hongjun Song
3. Fred H. Gage
4. P. Bonaldo
5. S. Morrison
6. F. Gattazzo
7. V. Horsley
8. Shenghui He

Citations in the corpus

• Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “In the past decades, significant progress has been made in describing stem cell niches at cellular, molecular, and functional levels in several model systems, including Drosophila germ line, mammalian skin, intestines , and bone marrow (reviewed by Li and Xie, 2005; Morrison and Spradling, 2008).”
• Mechanisms of stem cell self-renewal. (2009, background): “Most stem cells in metazoans reside within specialized microenvironments known as niches (Morrison & Spradling 2008).”
• Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus (2011, background): “Quiescence is one of the defining characteristics of stem cells in a range of tissues (Li and Clevers, 2010; Morrison and Spradling, 2008; Rossi et al., 2008).”
• Fibroblasts: origins, definitions, and functions in health and disease (2021, background): “Fibroblast plasticity It is emerging that fibroblast lineages are plastic and do not follow the canonical stem cell lineage model, in which undifferentiated and long-term self-renewing progenitors unidirectionally produce differentiated and, typically, postmitotic progeny (Morrison and Spradling, 20”
• Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. (2010, neutral): “The asymmetric segregation of molecules coupled with strictly oriented mitotic spindles can herald an asymmetric fate outcome of the stem cell division, as shown for the C. elegans embryo and the Drosophila neuroblast (Neumuller and Knoblich, 2009).”
• The aged niche disrupts muscle stem cell quiescence (2012, background): “These data are consistent with high levels of spry1 expression in quiescent SCs and RSCs 19 .”
• Biochemical analysis on microfluidic chips (2016, background): “Niches are complex microenvironments that regulate adult stem cell fate in vivo by molecular interactions [213] and are critical to maintain stem cells in their multipotent and often quiescent state.”
• BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “, intestinal crypts, hair follicle bulge in the skin) (153, 162, 247).”
• Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, background): “ior,maintaining a balance betweenquiescence, self-renewal and differentiation [20,21].”
• Centrioles, centrosomes, and cilia in health and disease. (2009, neutral): “(Morrison and Spradling, 2008).”