The biology of cancer stem cells.

By N. Lobo, Y. Shimono, Dalong Qian, M. Clarke. Annual Review of Cell and Developmental Biology, 2007

1,123 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b5437ee9825d99b9d2ed7849f38e8c7548718b22

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Oncology

Citations in the corpus

Hallmarks of cancer: the next generation. (2011, neutral): “CSCs are deﬁned operationally through their ability to efﬁciently seed new tumors upon inoculation into recipient host mice (Cho and Clarke, 2008; Lobo et al., 2007).”
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance (2011, positive): “Strict regulation of these fates is critical for HSC maintenance, and dysregulation of the balance between these fates is a common feature of blood malignancies (Lobo et al., 2007).”
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. (2009, positive): “Quiescence has been postulated to prevent stem cell exhaustion (Orford and Scadden, 2008) and is thought to help protect stem cells from acquiring mutations leading to their malignant transformation to putative cancer stem cells (Lobo et al., 2007; Park and Gerson, 2005; Wang and Dick, 2005).”
Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State (2012, background): “Although accumulating evidence has begun to support this notion (Dick, 2008; Lessard and Sauvageau, 2003; Lobo et al., 2007; Reya et al., 2001; Shimono et al., 2009), direct evidence has remained scarce thus far.”
Down-regulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells (2009, background): “Like the tissues from which they arise, solid tumors are composed of a heterogeneous population of cells, and many properties of normal stem cells are shared by at least a subset 592 Cell 138, 592–603, August 7, 2009 ª2009 Elsevier Inc. of cancer cells (Lobo et al., 2007; Stingl and Caldas, 2007).”
CD44: can a cancer-initiating cell profit from an abundantly expressed molecule? (2011, background): “The most frequent markers shared by CICs of different origins are CD20, CD24, CD34, CD44, CD90, CD117, CD133, aldehyde dehydrogenase (ALDH), nestin, the β1 integrin chain and EpCAM, and CD44 is the most frequently observed CIC marke”
Targeting cancer stem cell pathways for cancer therapy (2020, background): “60 Under this condition, a single CSC will form a cell colony or sphere.”
Nonequilibrium physics in biology (2019, methodology): “From the landscape analysis it was also found that, consistent with experiment (Li and Wang, 2015; Lobo et al., 2007; Marotta and Polyak, 2009), the cancer cell state re-emerges after eliminating all cancer cells.”
Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44 (2009, methodology): “Studies in the past have suggested that CSCs in several solid tumors showed greater resistance to anticancer chemotherapy drugs as well as to irradiation compared with the non-CSC population [9,23].”
P53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation (2008, positive): “The identification of TICs with stem-like properties in diverse human cancers including GBM represents an important conceptual advance in cancer biology with therapeutic implications 27, 28 .”
An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors (2008, background): “Additionally, some have proposed that cancer stem cells—a subpopulation of cancer cells possessing tumor-initiating capability—are derived from normal stem cell”