Molecular genetics of prostate cancer: new prospects for old challenges.

By M. Shen, C. Abate-Shen. Genes & Development, 2010

1,012 citations recorded by the source corpus.

Despite much recent progress, prostate cancer continues to represent a major cause of cancer-related mortality and morbidity in men. Since early studies on the role of the androgen receptor that led to the advent of androgen deprivation therapy in the 1940s, there has long been intensive interest in the basic mechanisms underlying prostate cancer initiation and progression, as well as the potential to target these processes for therapeutic intervention. Here, we present an overview of major themes in prostate cancer research, focusing on current knowledge of principal events in cancer initiation and progression. We discuss recent advances, including new insights into the mechanisms of castration resistance, identification of stem cells and tumor-initiating cells, and development of mouse models for preclinical evaluation of novel therapuetics. Overall, we highlight the tremendous research progress made in recent years, and underscore the challenges that lie ahead.

Subfields: Cancer Research, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/24d621c7f88e8aa5ec4eb73a867145057371981b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Hans Clevers
2. C. Sawyers
3. R. DePinho

In Pulmonary and Respiratory Medicine

1. John Wongvipat
2. Hans Clevers
3. C. Sawyers

Citations in the corpus

• Punctuated Evolution of Prostate Cancer Genomes (2013, neutral): “A representative immunohistochemical stain for the CDKN1B protein p27 shows discrete subclonal positivity in prostate cancer.”
• Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches (2022, background): “gland inflammation can shorten prostatic telomeres [78].”
• Identification of multipotent luminal progenitor cells in human prostate organoid cultures (2014, background): “…the epithelium: (1) secretory luminal cells marked by cytokeratin (CK) 8, CK18, androgen receptor (AR) and secretory proteins like prostate-specific antigen (PSA); (2) basal cells, identified by the expression of CK5, CK14, and p63; and (3) rare neuroendocrine cells (Shen and Abate-Shen, 2010).”
• Genetics and biology of prostate cancer (2018, background): “2; Shen and Abate-Shen 2010).”