Identification of human brain tumour initiating cells

By Sheila K. Singh, C. Hawkins, I. Clarke, J. Squire, J. Bayani, T. Hide, R. Henkelman, Michael D. Cusimano, P. Dirks. Nature, 2004

7,670 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/a7afdd381189f3a77eb81a409c9c291a8075423f

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CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells (2008, background): “This contrasts with previous experiments, which suggest that proliferation in vitro, and tumorgenicity in vivo is restricted to a CD133 positive cell subpopulation.(11,14) Our observation of CD133 negative cells giving rise to tumors that contain CD133 positive cells is more consistent with the conc”
The therapeutic promise of the cancer stem cell concept. (2010, background): “to be enriched among cell populations identified by a single prospective molecular marker not shared by the bulk cancer populations, for example, the CSCs in brain cancer (31), colon cancer (33, 34), pancreatic cancer (37), and Ewing sarcoma (40), all of which”
Transparent adult zebrafish as a tool for in vivo transplantation analysis. (2008, background): “Combinatorial Pigmentation Mutants Yield Transparent Adult Zebrafish The characteristic adult pigmentation pattern of the zebrafish consists of three distinct classes of pigment cells arranged in stripes (Figure 1A): black melanophores, reflective iridophores, and yellow xanthophores ( Rawls et al.,”
Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis (2009, background): “As few as 100 CD133 cells implanted in the forebrain of a nonobese diabetic–severe combined immunodeficient (NOD-SCID) mouse could reconstitute the tumor, and isolation of SC from this new tumor could be serially passed to other NOD-SCID mice (2, 3).”
Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients (2008, background): “from gliomas (4) as well as an isotype IgG2b control antibody (both”
The intestinal stem cell. (2008, background): “…has been highly successful in the identification of the hematopoietic stem cell from bone marrow (Spangrude et al. 1988) and—more recently—of cancer stem cells in leukemias (Bonnet and Dick 1997) and in solid tumors (Singh et al. 2004; Dalerba et al. 2007; O’Brien et al. 2007; Prince et al. 2007).”
A tumorigenic subpopulation with stem cell properties in melanomas. (2005, background): “normal and tumor tissues were isolated (3, 5, 40, 41), suggesting”