Polycomb silencers control cell fate, development and cancer

By Anke Sparmann, Maarten van Lohuizen. Nature Reviews. Cancer, 2006

1,410 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/436ee9be6fab7ec3324dc9ef49bef06c9076e17a

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Citations in the corpus

Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (2010, background): “During somatic development, Polycomb (PcG) and Trithorax (TrxG) group proteins serve conserved chromatin-based repressive and antirepressive roles in epigenetic memory of cell identity, for example, by controlling the expression of developmental regulators that drive differentiatio”
Polycomb group proteins: navigators of lineage pathways led astray in cancer (2009, positive): “Several genetic studies in different organisms have firmly established the vital and conserved roles for PcG proteins in embryonic development and adult somatic cell differentiatio”
MLL translocations, histone modifications and leukaemia stem-cell development (2007, background): “Abnormal TrxG or PcG function often results in aberrant gene expression that can lead to tumour development in model systems, suggesting that deregulation of these epigenetic programmes can initiate tumour formatio”
Evolution of the cancer stem cell model. (2014, background): “…epigenetic factors including members of the Polycomb group of transcriptional repressors (BMI-1 and EZH2) that are linked to normal stem cell self-renewal have been shown to exhibit variation in expression levels within tumors and play a role in tumor progression (Sparmann and van Lohuizen, 2006).”
Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains (2008, background): “Interplay between PcG complexes and modified histones has been proposed to mediate stable transcriptional repression [2,3].”
A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing (2007, background): “3b ) that maintain long-term gene silencing in diverse organisms and are essential for the normal state of stem and progenitor cells and their commitment to various tissue type”