Normal stem cells and cancer stem cells: the niche matters.

By Linheng Li, W. Neaves. Cancer Research, 2006

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Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth (2011, neutral): “, 2006), but the origin of many niche cells critical for tumor growth (Li and Neaves, 2006) has not been established.”
Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity (2008, background): “Whether such a CSC niche really exists and which cells constitute this niche in vivo remains to be established (23), but proving its existence or identification of the signals that regulate CSC proliferation and differentiation could be of vital importance for therapeutic strategies to prevent tumor”
The metastatic niche: adapting the foreign soil (2009, background): “Similarly, in stem cell biology the niche describes the specialized microenvironment that supports stem cell maintenance and actively regulates cell function and proliferatio”
CD44 is of Functional Importance for Colorectal Cancer Stem Cells (2008, background): “It is believed that CSC has the characteristics of normal adult stem cells including the selfrenewal property and multipotency for differentiation into distinct types of cells (4, 5).”
Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies (2020, background): “An important impact on this effect has the Wnt/ß-catenin pathway (46) that promotes HSC proliferation, independent of the bone marrow niche (5, 22, 499).”