A tense situation: forcing tumour progression

By D. Butcher, T. Alliston, Valerie M. Weaver. Nature Reviews. Cancer, 2009

1,903 citations recorded by the source corpus.

Cells within tissues are continuously exposed to physical forces including hydrostatic pressure, shear stress, and compression and tension forces. Cells dynamically adapt to force by modifying their behaviour and remodelling their microenvironment. They also sense these forces through mechanoreceptors and respond by exerting reciprocal actomyosin- and cytoskeletal-dependent cell-generated force by a process termed 'mechanoreciprocity'. Loss of mechanoreciprocity has been shown to promote the progression of disease, including cancer. Moreover, the mechanical properties of a tissue contribute to disease progression, compromise treatment and might also alter cancer risk. Thus, the changing force that cells experience needs to be considered when trying to understand the complex nature of tumorigenesis.

Subfields: Biomedical Engineering, Cell Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/369f87f0ccd5695ce6d995d662141a1ab8a29216

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Citations in the corpus

A Review of Optical Coherence Elastography: Fundamentals, Techniques and Prospects (2014, background): “This much higher value can be attributed to the stromal response associated with tumor progression, which results in the production of large quantities of collagen, causing a stiffening of the stroma surrounding tumor cells [76].”
The extracellular matrix at a glance (2010, background): “As a consequence, newly deposited and remodeled collagen and elastin fibers are reoriented and, thereafter, crosslinked by LOX and transglutaminase, thus generating larger, more-rigid fibrils that further stiffen the tissue ECM (Butcher et al., 2009; Erler and Weaver, 2009; Levental et al., 2009; Lu”
Mechanical control of tissue and organ development (2010, background): “Interestingly, neoplastic transformation might also involve alterations in the physical interactions between cells and the ECM that increase cell tension (Paszek et al., 2005; Butcher et al., 2009; Ingber, 2008; Bissell et al., 2005; Levental et al., 2009).”
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment (2010, background): “Mechanical forces contribute to tumor progression (Butcher et al., 2009), potentially by modulating proteolysis of ECM components.”
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin signaling (2009, background): “The tumor stroma is characterized by extracellular matrix (ECM) remodeling and stiffening, and tissue stiffness has been exploited to detect cancer (Butcher et al., 2009; Sinkus et al., 2000).”
Advantages of RGD peptides for directing cell association with biomaterials (2011, background): “Recent studies have revealed that the stiffness of the matrix is a critical regulator of cell adhesion, spreading, differentiation status, and survival [49,50].”
The role of mechanical forces in tumor growth and therapy (2014, neutral): “, metalloproteinases (MMPs) and lysil oxidase (LOX)) in order to increase matrix protein synthesis and crosslinking and decrease matrix proteinase activity (30-32), thereby increasing matrix stiffness (30).”
Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression (2015, background): “Overall, this results in the formation of a dense, fibrous tissue surrounding malignant, but generally not benign, tumors.(71) Concomitantly, this increased stiffness results in altered cellular behavior.”
Intrinsic extracellular matrix properties regulate stem cell differentiation. (2010, background): “Our review will only focus on stem cells, and we would refer the reader to the rich literature regarding cell– ECM interactions and the signaling that it induces in mature cells for a broader treatment of the subject (see (Butcher et al., 2009; Geiger et al., 2001; Nelson and Bissell, 2006; Schwartz”
YAP/TAZ at the roots of cancer (2016, background): “However, mechanical signals become progressively aberrant in cancer because of progressive deviations from normal tissue organization, inflammation, increased compression forces, changes in ECM composition and overall increase in ECM rigidity (Butcher et al., 2009).”
Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines (2011, background): “16) has been shown to promote cell contractility via changes in the actin myosin network (17).”