Exploiting tumour hypoxia in cancer treatment

By J. Brown, William R. Wilson. Nature Reviews. Cancer, 2004

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Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, positive): “Since oxygen tension varies widely between different parts of tumors (Brown and Wilson, 2004), we hypothesized that differences in myeloid cell migration between microenvironments, in part, represented differences in tissue oxygen tension.”
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “Intratumoral hypoxia prevents ROS formation, resulting in inefficient DNA strand breaks and IR resistance (Brown & Wilson, 2004).”
Regulation of PD-L1: a novel role of pro-survival signalling in cancer. (2016, background): “HIF-1 is a major oncogenic factor [72] and inhibition of HIF-1 has been applied for the treatment of cancer[73-75].”
Rational Approaches to Improving Selectivity in Drug Design (2012, background): “However, hypoxic conditions provide an opportunity for tumor-selective therapy, 163 including prodrugs activated by hypoxia such as tirapazamine 164 and banoxantrone (AQ4N).”