Dissecting the metastatic cascade

By K. Pantel, Ruud H. Brakenhoff. Nature Reviews. Cancer, 2004

1,350 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/16b2a78c2130a9b09a3beb9359327e91805d6c95

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Citations in the corpus

Tumor metastasis: mechanistic insights and clinical challenges (2006, background): “In other studies, tumor cells were identified in the blood or bone marrow, and correlated with poor patient outcome (reviewed in ref”
Matrix metalloproteinases and tumor metastasis (2006, background): “The role of lymphatic vasculature as a route for tumor cell dissemination has been established [151, 152], however it is not definitively confirmed how this route is related to the formation of metastases in secondary sites [2, 3].”
The Role of Snail in EMT and Tumorigenesis (2013, background): “The metastatic cascade is a complex process divided into a series of steps, including detachment of tumor cells from the primary tumor, invasion, intravasation, survival within the circulation, extravasation and colonization at the secondary site [77].”
Models, mechanisms and clinical evidence for cancer dormancy (2007, background): “jpg" NDATA ITEM> ]> The vast majority of cancer-related deaths are due to metastatic tumour growth that impairs the function of vital organ”
Glycogen Synthase Kinase-3 (GSK3): Inflammation, Diseases, and Therapeutics (2007, background): “Cells acquire an invasive capacity through changes in adhesiveness by proteolysis of the extracellular matrix and increased motility [173].”
The basics of epithelial–mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective (2019, background): “…cancer is the most common cancer in women globally, whereas about 90% of death of patients with breast cancer is caused by invasion and metastasis that are two important features of epithelial–mesenchymal transition (EMT) (Pantel & Brakenhoff, 2004; Elzamly et al., 2018; Sotiriou et al., 2003).”
Detection, clinical relevance and specific biological properties of disseminating tumour cells (2008, background): “Evidence indicates that BM is the common organ to which tumour cells from many types of carcinoma hom”
Parallel progression of primary tumours and metastases (2009, background): “Indeed, little is known in general about the phenotype of DTC”