Reactive oxygen species in cancer

By Geou-Yarh Liou, P. Storz. Free radical research, 2010

3,062 citations recorded by the source corpus.

Abstract Elevated rates of reactive oxygen species (ROS) have been detected in almost all cancers, where they promote many aspects of tumour development and progression. However, tumour cells also express increased levels of antioxidant proteins to detoxify from ROS, suggesting that a delicate balance of intracellular ROS levels is required for cancer cell function. Further, the radical generated, the location of its generation, as well as the local concentration is important for the cellular functions of ROS in cancer. A challenge for novel therapeutic strategies will be the fine tuning of intracellular ROS signalling to effectively deprive cells from ROS-induced tumour promoting events, towards tipping the balance to ROS-induced apoptotic signalling. Alternatively, therapeutic antioxidants may prevent early events in tumour development, where ROS are important. However, to effectively target cancer cells specific ROS-sensing signalling pathways that mediate the diverse stress-regulated cellular functions need to be identified. This review discusses the generation of ROS within tumour cells, their detoxification, their cellular effects, as well as the major signalling cascades they utilize, but also provides an outlook on their modulation in therapeutics.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fb3bb7aff96d65935d56da02246b981032d2635b

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Citations in the corpus

Gut Bacteroides species in health and disease (2021, background): “With Bfr, activation of the host’s spermine oxidase can occur, which, in turn, generates hydrogen peroxide and other reactive oxygen species that contribute to DNA damage, increasing the prevalence of cancer.(124,125) Recent research on enterotoxigenic Bfr has shown it to be a major initiator and pr”
Targeting Free Radicals in Oxidative Stress-Related Human Diseases. (2017, neutral): “stress via effective antioxidant mechanisms [27].”
The Immunomodulatory and Anti-Inflammatory Role of Polyphenols (2018, background): “Recent studies illustrated a direct correlation between ROS in intracellular signaling cascade and carcinogenesis [191].”
Enzyme Biosensors for Biomedical Applications: Strategies for Safeguarding Analytical Performances in Biological Fluids (2016, background): “Similarly, cancer, inflammation and infectious diseases, result in increased ROS production [155,156].”
Oxidative Stress in Cancer (2020, background): “In cancer cells, FOXO can induce genes for MMP-9 and MMP-13 and may therefore aid epithelial-to-mesenchymal transition (EMT) required for metastatic spread (Liou and Storz, 2010).”
The complexity of NF-κB signaling in inflammation and cancer (2013, background): “It is postulated that the innate immune response of neutrophils that release reactive oxygen species to kill invading pathogens might cause DNA-damage and thus genetic mutations as side effects, thereby triggering tumor initiation [83].”
Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy (2012, background): “Growth factors and cytokines too stimulate the production of ROS to exert their diverse biological effects in cancer [40, 41].”