A MicroRNA Signature of Hypoxia

By Ritu Kulshreshtha, M. Ferracin, Sylwia E. Wojcik, R. Garzon, H. Alder, Francisco J. Agosto-Perez, Ramana V. Davuluri, Chang-Gong Liu, Carlo Maria Croce, M. Negrini and 2 more. Molecular and Cellular Biology, 2006

1,078 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0428fdd26503702b829e64668c62a2c40ee0ad36

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Citations in the corpus

MicroRNA-155 Is Regulated by the Transforming Growth Factor β/Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA (2008, methodology): “Recent reports have indicated the importance of downregulation for miR-200 family miRNAs during TGF--induced EMT (2, 12, 22 , 36).”
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review (2012, neutral): “Another possibility that must be considered is the dynamic and immediate regulation in miRNA levels in stress response (Marsit et al, 2006) and in hypoxia (Kulshreshtha et al, 2007); thus, time of collection and processing could impact miRNA levels.”
MicroRNAs and complex diseases: from experimental results to computational models (2019, neutral): “For example, a specific spectrum of miRNAs including miR-23, miR-24, miR-26, miR-27, miR-103, miR-107, miR-181, miR-210 and miR-213 was induced in neoplastic cells under a hypoxic environment compared with normal conditions [117].”
MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2 (2009, neutral): “…with other studies demonstrating the repression of apoptosis by miR-210 during hypoxia in other cellular contexts (Fasanaro et al., 2008; Kulshreshtha et al., 2007), these data lend credence to a model in which miR-210 carries a maladaptive role during normoxia, causing a mismatch of…”
Hypoxia-Inducible Factors in Physiology and Medicine (2012, background): “These results indicate that HIF-dependent repression occurs via indirect mechanisms, which include HIF-1-dependent expression of transcriptional repressors (Yun et al., 2002) and microRNAs (Kulshreshtha et al., 2007).”
miR-21: a small multi-faceted RNA (2008, background): “Interestingly, miR-21 is one of the miRNAs consistently induced in response to hypoxia, as demonstrated in breast and colon cancer cells [44].”
MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators (2008, background): “Another factor that can induce miR-21 expression is hypoxia, a general feature of all solid tumors (30).”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “MiRNA expression can be controlled by transcription factors and possibly other miRNA in response to a variety of endogenous and exogenous stimuli [63-69].”
Hypoxia inducible mir-210 regulates normoxic gene expression involved in tumor initiation (2009, positive): “Since several other miRNAs are also hypoxia inducible (Kulshreshtha et al., 2007) (Figure S1) the 50 genes in the list may include their targets as well.”
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. (2008, background): “…to directly activating transcription via HREs at the target gene locus, the HIF pathway is extended by secondary transcription factors under HIF transcriptional control, activity on noncoding miRNAs (Kulshreshtha et al., 2007), and nonHRE-mediated interactions with other signaling pathways.”
The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 (2008, background): “…miR-103/7 are differentially expressed in a number of contexts, including during development (Esau et al., 2004; Miska et al., 2004), neoplastic transformation (Roldo et al., 2006), hypoxia (Kulshreshtha et al., 2007), and both cold and heat stress (Marsit et al., 2006; van Rooij et al., 2006).”
Role of microRNAs in vascular diseases, inflammation, and angiogenesis. (2008, background): “Of note, miRNA profiles of cancer cells revealed that at least a subgroup of hypoxia-regulated miRNAs are induced by hypoxia inducible factor (HIF), supporting the key role of HIF as transcription factor for miRNA expression during hypoxia.(39) This finding might also be of importance to understand ”