Tumor cell metabolism: cancer's Achilles' heel.

By Guido Kroemer, J. Pouysségur. Cancer Cell, 2008

2,297 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fe48eb11330ed5d0a817eb762b33fe8b3f4ed1a3

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Citations in the corpus

MicroRNA Functions in Stress Responses (2010, positive): “…(Kultz, 2005), such as induction of molecular chaperones (Buchberger et al., 2010; Richter et al., 2010), rapid clearance of damaged macromolecules (Kroemer et al., 2010), growth arrest, activation of certain gene expression programs (Spriggs et al., 2010), and, when cells can no longer cope with…”
The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism (2014, background): “Altered metabolism is a universal property of most, if not all, cancer cells [1] [2].”
Hallmarks of cancer: the next generation. (2011, positive): “Thus, both the Ras oncoprotein and hypoxia can independently increase the levels of the HIF1 a and HIF2 a transcription factors, which in turn upregulate glycolysis (Semenza, 2010a, 2010b; Kroemer and Pouyssegur, 2008).”
Metabolic Induction of Trained Immunity through the Mevalonate Pathway. (2018, positive): “There, the citrate is converted back into acetyl-CoAbyATP citrate lyase (Kroemer and Pouyssegur, 2008) and enters either the mevalonate pathway or fatty acid biosynthesis (Thurnher and Gruenbacher, 2015).”
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis (2010, background): “…cells from a normal to cancerous state is accompanied by reprogramming of metabolic pathways (Deberardinis et al., 2008b; Jones and Thompson, 2009; Kroemer and Pouyssegur, 2008), including those that regulate glycolysis (Christofk et al., 2008; Gatenby and Gillies, 2004), glutaminedependent…”
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme (2011, background): “This phenotype may promote a state of apoptosis resistance (Plas and Thompson, 2002; Kroemer and Pouyssegur, 2008), the generation of biosynthetic precursors for proliferation (Vander Heiden et al., 2009), and increased in vasive ability (Stern et al., 2002).”
Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited (2010, background): “These, together with the activation of hypoxia-inducible factor (HIF), a transcription factor that is activated by hypoxic stress but also by oncogenic, metabolic, and oxidative stress, often lead to the overexpression of the glucose transporters and various glycolysis pathway enzymes or isozyme sub”
Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. (2011, background): “The protons derived from CAIX activity further contribute to the decrease in pHe, thereby potentiating extracellular matrix breakdown and cell invasion (6, 19).”
Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer (2009, background): “…glucose metabolism is a common consequence of many of the mutations responsible for human cancer, and therefore may be a central process essential for tumor growth (Flier et al., 1987; Shim et al., 1997; Osthus et al., 2000; Elstrom et al., 2004; Matoba et al., 2006; Kroemer and Pouyssegur, 2008).”
Flavonoids as Anticancer Agents (2020, background): “There is emerging evidence that cancer is a metabolic disease determined by various degrees of mitochondrial dysfunctions and metabolic alterations [38,39,41].”