2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

By N. Mabjeesh, D. Escuin, T. Lavallee, V. Pribluda, G. Swartz, Michelle S. Johnson, M. Willard, H. Zhong, J. Simons, P. Giannakakou. Cancer Cell, 2003

721 citations recorded by the source corpus.

Subfields: Biochemistry, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/64ba4a8a64c862dca6a12bd3cf388a0e6e5c3fb4

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Citations in the corpus

HIF-1 as a target for drug development (2003, background): “demonstrated that 2-ME2 inhibits HIF-1α at the post-transcriptional level, prevents HIF-1 target gene expression in tumour cells and inhibits HIF-2α in human endothelial cell”
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. (2016, background): “…PEG-SN38 Topoisomerase 1 Rapisarda et al., 2004, Pastorino et al., 2010 EZN-2968 HIF-1α mRNA Greenberger et al., 2008 2ME2, ENMD-1198 Microtubules Mabjeesh et al., 2003; LaVallee et al., 2008 Geldanamycin and analogs Hsp90 Isaacs et al., 2002 Vorinostat HDAC Hutt et al., 2014 YC-1 unknown Chun…”
Exploiting tumour hypoxia in cancer treatment (2004, background): “Mabjeesh and colleagues reported that microtubule inhibitors such as 2-methoxyestradiol, vincristine and paclitaxel reduce HIF-1α levels in vitro apparently by inhibiting translation of HIF-1α mRN”
Hypoxia and hypoxia-inducible factors (HIFs): master regulators of metastasis (2010, background): “Disruption of microtubule polymerization by 2-methoxyestradiol reduced HIF-1a protein level and xenograft tumor growth (63).”
Targeting HIF-1 for cancer therapy (2003, background): “Finally, disruption of microtubule polymerization by 2-methoxyoestradiol (2ME2) has also been shown to result in decreased HIF-1α levels and decreased VEGF mRNA expression in cultured cell”